Journal of Bacteriology & Parasitology

In vitro immune modulation of Salmonella enterica serotype pullorum

3^rd International Congress on Bacteriology and Infectious Diseases

August 04-06, 2015 Valencia, Spain

Ying Tang, Paul A Barrow, Michael A Jones and Neil Foster

Posters-Accepted Abstracts: J Bacteriol Parasitol

Abstract:

Salmonella enterica infection affects a wide range of animals andhuman.The avian specific serotype S.Pullorum infection
produces systemic disease followed by a carrier state in convalescencebirds. In comparison with S. Enteritidis, S. Pullorum
has been found to induce increased levels of IL-4 and lower levels of IFN-γ in the spleen of infected birdswhich may switch
the immunity from a pro-inflammatory to an anti-inflammatory response.Different immune responses between persistent
Salmonella (S. Pullorum) and non-persistent (S. Enteritidis and S. Gallinarum) serotypes werecompared ex vivo using
Salmonella-infected macrophages and CD4+T lymphocytes. In comparison with S. Enteritidis and S. Gallinarum which induced
an IFN-γ-producing Th17 response, macrophages infected with S. Pullorum had a reduced expression of IL-18 and IL-12α and
stimulated proliferation of Th2 lymphocytes with reduced IFN-γ and increased IL-4.However, our data shows no evidence
of clonal energyorimmune suppressioninduced by S. Pullorum. In conclusion, S. Pullorum modulates host immunityfrom a
dominant IFN-γ-producing Th17 response towards a Th2 response which may promote the persistent infection in chickens.

Biography :

Ying Tangobtained an MSc in preventive veterinary medicine from Sichuan Agriculture University, P.R.China in 2012. His research program in MSc was the study on
construction and immunogenicity of PEDV/ TGEV DNA vaccine, which was completed in Key Laboratory of Animal Disease and Human Health of Sichuan Province,
China. During my master’s degree I have also completed another work in isolation and identification of Japanese B encephalitis virus, which was part of a research
program on pathogen and hazard risk of zoonoses in earthquake affected area in Sichuan.