Health Care : Current Reviews

In silico study on Liv-Pro-08 an oral ayurvedic formulation on NAFLD

3^rd Indo-Global Summit & Expo on Healthcare

October 05-07, 2015 New Delhi, India

M Suriyavathana

Periyar University, India

Posters-Accepted Abstracts: Health Care: Current Reviews

Abstract:

In an attempt to identify suitable ligands for NAFLD, bioactive compounds from indigenous plant species were used. The biological markers namely CYTP450E1 and ACC1 were chosen for the study. A class of novel compounds targeting liver protection, Liv-Pro-08 was characterized. Interaction analyses of these compounds were performed by molecular docking and energy optimization methods. Out of the library of ligands prepared including eight compounds, which successfully docked with the chosen targets; two were found to provide an optimal interaction. Intermolecular interactions reveal participation of charged residues as Lys and Arg at specific positions. Target preferences were exhibited among the interacting molecules based on binding energy and H-bond interaction. The interacting distances were determined for the compounds that exhibited optimal binding with the NAFLD targets. These compounds are found to provide promising lead for development of novel drugs for liver diseases.

Biography :

Email: suriyaveda@yahoo.co.in