Journal of Dermatitis

IECLPPP-Immunohistochemical Expression of Cornulin in Lesional and Perilesional Skin of Plaque Psoriasis

22^nd World Dermatology Congress

September 27-28, 2021 | Webinar

Amina Mohamed Ayad

Menoufi a University, Egypt

Scientific Tracks Abstracts: J Dermatitis

Abstract:

Background: Psoriasis is an immune-related disorder with dermal infl ammation and epidermal hyperplasia. Cornulin (CRNN) has a signifi cant role in keratinocyte proliferation and stimulates infl ammation in psoriasis. Aim of the Work: This work aims to evaluate CRNN’s expression values in lesional and perilesional psoriatic skin compared with the control group’s skin through immunohistochemistry. Methods: This case–control study included 30 cases with plaque psoriasis and another 30 as controls. Patient samples were collected and immunohistochemical staining of Cornulin was conducted. Results: In the epidermis; there was a stepwise pattern of signifi cant Cornulin overexpression in keratinocytes starting from controls (34.00 ± 23.65) to lesional (62.59 ± 23.93) passing through perilesional skin (36.52 ± 18.49) (P < 0.001). Moreover, there was also a stepwise pattern of the signifi cance of Cornulin starting from 4 in controls (13.3% for both) to 28 lesional cases (93.3%) and 18 (60.0%) passing through 17 perilesional skin cases (56.7%) and 5 (16.7%) (P < 0.001 for both) for infl ammatory cells and adnexa, respectively. A signifi cant relationship between lesional epidermal Cornulin’s strong intensity and a higher H score and both hyperkeratosis and parakeratosis was found (P =0.008 for both intensity and 0.028 for both H scores). Conclusion: Cornulin might be implicated in keratinocyte hyperproliferation and infl ammation in psoriasis vulgaris and may be valuable as targeted therapy.

Biography :

Amina Ayad had graduated from Kasr AL Ainy school of medicine,Cairo university,she is adermatologist, and she is now completing Master degree at Menoufi a University.