Journal of Blood Disorders & Transfusion

Idiopathic thrombocytopenic purpura

International Conference on Hematology & Blood Disorders

September 23-25, 2013 DoubleTree by Hilton Hotel Raleigh-Durham Airport at RTP, NC, USA

V. Satya Suresh Attili

Scientific Tracks Abstracts: J Blood Disord Transfus

Abstract:

Idiopathic Thrombocytopenic Purpura (ITP) mostly responds well to steroids. Steroid refractory ITP, though not so common, forms a major challenge in the regular practice of hematologists, more so in developing nations in view of cost and expertise constraints. While most of them agree and adopt spleenectomy as their choice, the induction therapy to shoot the platelets to optimal levels still remains varies among the practitioners. Though options like Intravenous Immunoglobulin (IV Ig), rituximab are standard and known to cause rapid, predictable and usually short lived raise in platelet counts, their use is limited by the costs. Alternatives like Anti-D and vincristine, were also been tried with varied success. This review of hospital records is an attempt to retrospectively look into the practice patterns and the cost-effective analyses of the top four modalities used prior to spleenectomy and present a summary. The average results suggest that in patients, who don?t have life threatening disease, vincristine is still one of the excellent options and the results are comparable with the other standard treatments. However in case of need for rapid response, Anti- D still remains good option in Rh+ cases, as it is more cost effective than IV Ig or rituximab before spleenectomy. However due to non uniformity of adverse event reporting the later though was performed, not reported in the abstract.