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Human metapneumovirus A/B acute respiratory infections in children in a central-east region of Tunisia
Joint Event on 4th International Conference on Drug Discovery, Designing Chemistry and Pharmaceutical Analysis & International Conference on Biobetters and Regulatory Affairs
June 27-28, 2018 | Vancouver, Canada
Ines Brini
University of Sousse, Tunisia
Posters & Accepted Abstracts: J Bioequiv Availab
Abstract:
The aim of this study was to describe Acute Respiratory Infections (ARIs) by human metapneumovirus A/B (hMPV A/B) from hospitalized infants and children (aged 1 month-5 years) in Farhat Hached University-Hospital of Sousse, Tunisia. During the period from September 2013 and December 2014, nasopharyngeal aspirates were obtained from 372 subjects and tested for the presence of hMPV A/B and other respiratory viruses using multiplex real-time RT-PCR. The distribution of hMPV A/B infection and its association with demographic information of patients and clinical symptoms were analyzed. In general, in 342 (91.9%) of the samples, at least one pathogen was detected. The hMPV A/B was decribed in 16.1% (60/372) of tested speciemens, and was more described in multiple infections (96.7% from total hMPV A/B infections). The hMPV A/V was more frequent in children aged 1???3 months (5.9% of enrolled samples), in male cases (66.7%), in subjects living in urban environment (66.7%), in primary care at home and not in daycare (60.0%), and 60.0% were living with siblings. Regarding ARIs, 10.0% of infected cases were admitted in intensive care unit, 75.0% of cases were diagnosed for bronchiolitis, and 18.3% had rhinitis. In addition to hMPV A/B ARIs, 23.3% of subjects had bacteria super-infection. A total of 5/60 hMPV A/B infected cases ended fatal. This study described the high prevalence of hPMV A/B ARIs in infants and children in Sousse, Tunisia. Such findings will be helpful for the better understanding of its circulation and for the implementation of prevention strategies in the community.
Biography :
E-mail: ines.brini@hotmail.com