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Hematopoietic stem cell transplantation
4th International Conference on Blood Malignancies & Treatment
April 18-19, 2016 Dubai, UAE
Amandeep Kaur
Himalayan University, India
Khalsa College of Nursing, India
Posters & Accepted Abstracts: J Blood Disord Transfus
Abstract:
During the past 25 years, hematopoietic stem cell transplantation (HSCT) has been accepted as routine treatment for many patients with hematologic malignancies. Hematopoiesis is the process by which all cellular elements of the blood develop. This highly complex and tightly regulated biological function is characterized by the stimulation of the pluripotent hematopoietic stem cell by various glycoproteins known as hematopoietic growth factors (HGFs). Recent laboratory and clinical observations on the biology of transplantation have challenged many of the fundamental beliefs and practices established over the past quarter century. Stem cell transplants are most often used to help people with leukemia and lymphoma. They may also be used for neuroblastoma and multiple myeloma. HSCT can be described according to the relationship between the patient and the donor and by the anatomic source of stem cells. Syngenic donors represent the best source of stem cells; unlike the use of allogenic donors, there is no risk of graft versus host disease (GVHD) and unlike the use of autologous marrow, there is no risk of the stem cells been contaminated with tumor cells. The procedure of HSCT includes diagnostic tests, initial chemotherapy, granulocyte colony-stimulating factors, Hickman catheter insertion, conditioning treatment, stem cell infusion, and supportive medication. The high doses of cancer treatment that one has before a stem cell transplant can cause problems such as bleeding and an increased risk of infection. Recent research found that novel stem cell line avoids risk of introducing transplanted tumours. Sleep deprivation affects stem cells and may reduce transplant efficiency.
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