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Genetic association of interferon gamma induced protein-10 (IP-10), CXCL-10 gene polymorphisms with TB pleurisy susceptibility in South Indian population
7th Middle East - Global Summit and Expo on Vaccines & Vaccination
September 28-29, 2015 Dubai, UAE
Sheikh Ghousunnissa
Lepra Blue Peter Public Health & Research Centre, India
Posters-Accepted Abstracts: J Vaccines Vaccin
Abstract:
Background: Chemokines are involved in both innate and adaptive responses. Tuberculosis pleurisy may be caused due to spread of infected macrophages/ monocytes trafficking from the lung. CXCL-10 known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine 10 is 8.7 Kda protein, which is secreted in response to IFN-?³ by monocytes, endothelial cells and fibroblasts. It has chemo-attraction for monocytes/macrophages T cells, NK cells and dendritic cells in promotion of T cell adhesion to endothelial cells. Aim: In the present study, we investigated whether polymorphisms in CXCL-10 gene have any role contributing to disease manifestation of TB pleurisy. Materials & Method: Two SNPs in CXCL-10 promoter (â??1447A>G and â??135G>A) were genotyped in 186 TB Pleurisy, 159 Pulmonary TB patients and 205 healthy subjects by PCR-RFLP. Disease associations were examined by Ï?2 Fisher exact test. Results: Polymorphisms in the promoter region (â??135G>A) genotype GA and allele G frequency were significantly high (p<0.05) in TB subjects compared to healthy controls. The genotype AA and allele A was significantly low (p<0.05) with TB pleurisy subjects compared to healthy controls. The frequency of haplotype A-G combination of (1447A>G and â??135 G>A) was significantly high (p<0.05) in TB pleurisy. Conclusions: Our results reveal that genotype GA and allele G frequency at (â??135G>A) position were strongly associated with rendering susceptibilityto tuberculous pleurisy. The GA genotype may be a useful genetic marker for early detection of the disease in high risk individuals.
Biography :
Sheikh Ghousunnissa is pursuing her PhD final year under the Supervision of Dr. Vijaya Lakshmi Valluri from Genetics Department, Osmania University.
Email: nissa782006@gmail.com