Journal of Bioequivalence & Bioavailability

Formulation and Evaluation of interpenetrating polymer network (IPN) hydrogel microparticles of theophylline for controlled drug delivery

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Tapan Kumar Giri and Dulal Krishna Tripathi

Posters: J Bioequiv Availab

Abstract:

H ydrog els can be prepared as three-dimentional hydrophilic networks that are capable of absorbing large amount of water or biological fluids and release drugs at controlled rates. In recent years, IPN hydrogels for biomedical applications has attracted the attention for researchers. IPN structure is obtained when at least one polymer network is synthesized and/or crosslinked in the immediate presence of the other. Xanthan gum was derivetized to sodium carboxymethyl xanthan gum. Then IPN hydrogel microparticles of sodium carboxymethyl xanthan gum and casein were prepared by ionotropic gelation process using AlCl 3 as a crosslinking agent. Theophylline was used as model drug. Theophylline is one of the most important drugs for the treatment of asthma and recent studies indicated that it has anti-inflammatory effects. Thus great attentions have been shown due to its new effect on the treatment of asthma. Unfortunately, since its short half-life (6 hours), conventional dosage forms have to be administered 3-4 times a day in order to avoid large fluctuations in plasma concentrations, which lead to poor patient compliance. Sustained release dosage forms can overcome this drawback. The effect of different formulation variables on the extent of release of theophylline was examined. The study indicated that the IPN hydrogel microparticles release minimum amount of drug in simulated gastric fluid and controlled the drug release in simulated intestinal fluid. These hydrogel microparticles seem to be a promising for sustained drug delivery system