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For dentists and doctors: The neglected concepts about the factors influencing the effects of drugs
14th International Conference on Dental Health
September 14-16, 2016 Philadelphia, USA

Abdelaziz Ghanemi

University of Chinese Academy of Sciences, China

Posters & Accepted Abstracts: Dentistry

Abstract:

The study or the evaluation of the effects of not only an active compound, mainly drugs but also a toxic compound always takes into consideration well- known influencing factors such as the drug concentration, drug´┐Ż??drug interactions or the type of excipient or solvent used during the drug administration. However, some factors can significantly influence the activity a drug or a compound can have on cells, tissues or organisms. Drug metabolism parameters in addition to the physiological or the pathological status of the cells, the tissue or the patients represent other elements that should be considered as well. Indeed, a slow or an active metabolism (due to genetic factors or alcohol abuse for example) wills influence drug elimination and, importantly, the metabolism will be more obvious when the drug is used to treat metabolic diseases. Physiological or pathological situations might exert influence at different levels including both pharmacodynamics and pharmacokinetics. For example a pregnant woman will produce steroid hormones that may have the same blood transporters as steroids drugs, an athlete would have a better drug metabolism than a sedentary patient and a diabetic patient would respond less to antihyperlipidemic agents compared to non-diabetic patients if they are given to both patients in the same dosage. These factors should be considered by both clinicians while prescribing therapies and researchers working on experimental pharmacology to develop pharmacology toward optimized laboratory conditions and more efficient clinical applications.

Biography :

Email: ghanemiabdelaziz@hotmail.com