Journal of Blood Disorders & Transfusion

FLT3 mutations and their effect on overall survival

4^th International Conference on Blood Malignancies & Treatment

April 18-19, 2016 Dubai, UAE

Sadaf Shahab, Khaleeq un Nisa, Muhammad Nadeem, Danish Zahid, Saqib Ansari, Tasneem Farzana, Mehwesh Taj, Munira Borhany, Nuzhat Ahmed and Tahir S Shamsi

National Institute of Blood Diseases and Bone Marrow Transplantation, Pakistan

Posters & Accepted Abstracts: J Blood Disord Transfus

Abstract:

Acute myeloid leukaemia (AML) is a disease of heterogenic nature. Almost one third AML patients have normal karyotype and fall in a standard risk group. Substantial proportion of AML cases possess normal karyotype and categorized by the presence of prognostic markers such as FLT3-ITD,(Internal Tandem Duplication) and TKD (Point Mutation), NPM1 and CEBPA. Tyrosine kinases mutations triggers constitutive tyrosine phosphorylation, enhance cell proliferation and development of hematologic malignancies. The clinical and prognostic relevance of the ITD mutations are reported by various authors. The association of FLT3 mutations with outcome is very important. In order to investigate the role of those mutations on overall survival present study was conducted. This was an observational cross sectional study performed at National Institute of Blood Diseases and Bone Marrow Transplantation (NIBD), from May 2010 to October 2015. About100 AML patients diagnosed on the basis of WHO classification of myeloid neoplasms 2008 were included in the study. Polymerase Chain Reaction was used to detect FLT3 mutation from peripheral blood samples. We performed Polymerase Chain Reaction and Gel Electrophoresis. The data was analysed with SPSS version 20 and independent samples t-test was performed at significance level (0.05).

Biography :

Email: sadaf_shahab99@yahoo.com