Journal of Bioequivalence & Bioavailability

Evaluation of chitosan-hydroxy propyl methyl cellulose as a single unit hydrodynamically balanced sustained release matrices for stomach specific delivery of Piroxicam

7^th World Congress on Bioavailability & Bioequivalence: BA/BE Studies Summit

August 29-31, 2016 Atlanta, USA

Shashank Soni, Anurag Verma and Veerma Ram

Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, India
IFTM University, India

Posters & Accepted Abstracts: J Bioequiv Availab

Abstract:

The purpose of investigation is to find out the potential of chitosan (CH) and hydroxy propyl methyl cellulose (HPMC) derivatives loaded with piroxicam (PRX) for delivering into the stomach by using gastroretention technology. These single unit hydrodynamically balanced system capsules (HBS capsules) were prepared by manual hand shaking method followed by filling in empty hard gelatin capsule shell. The formulations were evaluated for drug-excipient interaction by using Fourier transform infrared spectroscopy (FTIR), and by thermogravimetric analysis (TGA), differential thermal analysis (DTA) and derivative thermo gravimetric analysis (DTG). In vitro buoyancy studies, in vitro characteristics, long term stability studies and curve fitting analysis were also performed. FTIR and TGA/DTA/DTG thermograms represents that the there is no drug excipient interactions. All the formulations (F1-F12) remained buoyant till the time of drug release without any lag time. Release profile of formulations in HCl; 0.1 mol L-1 shows the release up to 90% without sinking in the dissolution media. Long term stability studies for formulations (F5, F6 and F12) period of 12 months are stable through the period when compared with normal (F5, F6 and F12) without showing any significant difference. The similarity factor value (f2) was found to be 85.45, 88.98, and 86.78 respectively for F5, F6 and F12 formulations. Curve fitting analysis represents the formulation (F1-F5) shows the zero order kinetics while formulation (F6- F12) followed the Higuchi model on the basis of their r2 value. Our obtained result suggests that CH, HPMC and in combination of HPMC and CH loaded with PRX is an excellent biopolymer for sustained delivery of drug from single unit hydrodynamically balanced system capsule.

Biography :

Email: shashank_soni64@yahoo.com