Journal of Bioequivalence & Bioavailability

Evaluating aloe vera powder as bioavailability enhancer

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

Vamshikrishna and Habibur Rahman

Posters: J Bioequiv Availab

Abstract:

Objective: The object of the present investigation is to evaluate the aloevera freeze dried powder to improve the solubility of curcumin. To characterize the aloevera freeze dried powder for its compatibility with drugs. Methods: Curcumin is formulated as tablets with different ratios of aloevera powder. Characterization of aloevera includes solubility, IR scan, UV absorption curve, the inertness of the aloevera powder and compatibility with curcumin was analyzed by UV and IR scans for the compatibility. The solubility studies were performed in different pH and solvents for curcumin and the inclusion of aloe vera shows a better solubility profile for curcumin. The trail batches were formulated to find the better ratio of aloevera to increase the solubility , thereby the bioavailability of curcumin. Curcumin is formulated as tablets by direct compression method. Results: The prepared tablets were subjected for the quality control studies. In vitro release studies suggest that the release profile of curcumin was found to be better with aloevera powder. The concentration of aloevera is directly proportional to the drug release. It is evident that aloevera can be used as a bioavailability enhancer. Conclusion: To conclude, aloevera freeze dried powder can be further evaluated for increasing the sol