Journal of Bacteriology & Parasitology

Epidemiology of Tropheryma whipplei

3^rd International Congress on Bacteriology and Infectious Diseases

August 04-06, 2015 Valencia, Spain

Alpha Kabinet Keita

Posters-Accepted Abstracts: J Bacteriol Parasitol

Abstract:

Tropheryma whipplei, which causes Whipple’s disease (WD), is detected with variable prevalence in human stool and saliva.
We investigate the epidemiological factors which influence the bacterium natural history. For this purpose, molecular and/
or serological studies was performed in entire population of 2 villages in Senegal (Dielmo and Ndiop), in homeless people and
in family in Marseille-France. T. whipplei was identified in 31.2% of the stool (139/446) and 3.5% of saliva (13/370) obtained
from healthy subjects in Senegal. The carriage in the stool was significantly (p<10-3) higher in children who were between
0 and 4 years old (60/80, 75%). In homeless peoples the prevalence of T. whipplei in stools was 12.9% (21/162) and 37.5% of
stools (24/64) and 10% of saliva (7/70) in relatives of patients with Whipple disease or chronic carriers. Regarding findings
from phylogenetic analysis, we identified in Senegal 22 genotypes, 16 of which were new. Among these, specific and epidemic
genotypes were identifying. Overall, the same circulating genotype was common all population. Important seroprevalence and
seroconversion was detected in all population. Our findings show that T. whipplei is a common and contagious bacterium that
is contracted early in childhood. Epidemic genotypes associated with absence of the bacterium in water, arthropods vector;
almost no presence (<1%) in domestic animals and dust suggest a human transmission of T whipplei.

Biography :

Alpha Kabinet Keita obtained his medical degree at the Faculty of Medicine of the Gamal Abdel Nasser University in Guinea-Conakry in 2007, completed Master
degree in 2010 and PhD in infectious diseases and Microbiology in 2013 at Aix-Marseille University in France. Currently, he is Post doctoral Research Scientist at
Institut de Recherche pour le Développement (IRD) in Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) at Dakar (Senegal).
He has published 09 scientific papers in reputed journals and his research interests include epidemiology of infectious diseases, Tropheryma whipplei agent of
Whipple’s disease, malaria and non malaria fever.