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Epidemiology and Genotype distribution of Rotavirus gastroenteritis in under five children of South Rajasthan
39th Euro Global Summit and Expo on Vaccines & Vaccination
July 05-06,2021 | WEBINAR
Bhupesh Jain
Rajasthan, INDIA
Scientific Tracks Abstracts: J Vaccines Vaccin
Abstract:
Introduction: Rotavirus is the most common cause of severe diarrhea in infants and young children worldwide. The burden of rotavirus diarrhea in children of South Rajasthan, India is not well established. The present study was conducted to determine the epidemiology of rotavirus diarrhea and its genotypes distribution among under five children from Udaipur, Rajasthan. Methods: Hospital-based, prospective study among children aged 0-59 months of age hospitalized due to acute gastroenteritis and assess the clinical and epidemiological profile. Stool samples collected during 2017-2019 from 734 children, were tested by enzyme immune assay (EIA) to identify rotavirus and the samples that were positive were subjected to genotyping using published methods. Results: Rotavirus was detected in 12.94% (95/734) of the stool samples. Maximum positivity (38.9%) was seen in children aged 12-23 months followed by 34.7% in 6-11 months of age. Detection rates were higher (46.31%, 44/95) during winter months of December-February. 65% children with rotavirus diarrhea had severe dehydration followed by moderate dehydration in 32% of cases. G3P[8] (40, 43.01%) was the commonest genotype followed by G9P[4] (10,10.75%). Conclusion: 12.9% of children were rotavirus positive with predominant (43.01%) circulation of G3P[8] strains among under five children hospitalized due to acute gastroenteritis in a tertiary care setting in Udaipur, Rajasthan.