Journal of Bioequivalence & Bioavailability

Enhancement of bioavailability of an anti-migraine drug using mouth dissolving formulation

9^th World Congress on Bioavailability and Bioequivalence

April 16-18, 2018 Dubai, UAE

Jadhav Sachin M, More Vrunal V, Khule Prajakta K and Mandave Satish V

Shri Vithal Education & Research Institute-College of Pharmacy, India

Posters & Accepted Abstracts: J Bioequiv Availab

Abstract:

The demand for mouth dissolving tablet (MDT) has been growing during the last decade especially for patients who require faster action. In present work mouth dissolving tablets of Rizatriptan Benzoate were prepared using sodium starch glycolate, croscarmellose sodium, crospovidone as superdisintegrants by direct compression method. The prepared tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug-polymer interaction by drug content water absorption ratio, wetting time, in vitro drug release, FTIR studies and DSC studies. The tablets passes a weight variation in the range 193 to 207 mg which is below ±7.5%, hardness of 2.0 to 4.0 Kg/cm², percentage friability of 0.36 to 0.89%, disintegration time of 20 to 80 seconds, drug content uniformity was in between 97.01±0.68 to 99.63±0.97% water absorption ratio of 48 to 80%, wetting time of 24 to 83 seconds and in vitro drug release showed in the range 80-99.87% and formulation F4 showing 99.87% drug release within 8 minutes. From FTIR and DSC studies results reveals that there is no interaction between drug and any other formulation excipients. Stability study results reveal that there is no change in disintegration, wetting time and drug content of tablets prepared by direct compression. The results concluded that mouth dissolving tablets of Rizatriptan Benzoate containing croscarmellose showing enhanced dissolution will lead to improved bioavailability and effective therapy. srksmj@gmail.com