Journal of Stem Cell Research & Therapy

Endogenous stem cells as a treatment for celiac disease, a case report

4^th International Conference and Exhibition on Cell & Gene Therapy

August 10-12, 2015 London, UK

Henry E Young1 and Asa C Black2

Posters-Accepted Abstracts: J Stem Cell Res Ther

Abstract:

A 59-year old male presented with abdominal discomfort, diarrhea, headaches, fatigue, and bone and joint pain of long
standing duration. Underlying complications included Hashimoto’s thyroiditis, Sjögren’s disease, autoimmune induced
insulin-dependent diabetes, and systemic lupus erythematosus. A sheep red blood cell agglutination test was utilized to detect a
numerical value for antibodies to serum-containing antigens. A value of >1.0 designates sufficient circulating immunoglobulins
to an antigen to cause an allergic response to that antigen. Based on a value of 73 to the gluten antigen, gliadin, a diagnosis
of Celiac disease was made. Between 2011 and the present the patient was placed on a gluten-free diet and treated with
8 endogenous totipotent stem cell-pluripotent stem cell transplants, i.e., one autologous, one autologous/allogeneic, three
chimeric/allogeneic, and three chimeric. The stem cell transplants entailed daily ingestion of a nutraceutical to stimulate
endogenous stem cell proliferation in situ and ingestion of a second nutraceutical prior to harvest to maximize endogenous
stem cell capture. The endogenous stem cells were then harvested and segregated by size and unique cell surface markers
into individual populations of totipotent stem cells and pluripotent stem cells. The endogenous stem cells were activated and
infused systemically into directed sites. Following the 8th stem cell treatment an agglutination test for the gluten antigen
gliadin was performed and demonstrated a numerical value of 0.01. As shown, endogenous totipotent stem cell-pluripotent
stem cell transplants can modulate the immune system, reversing allergic symptoms in persons with an allergy to gluten.