Modern Chemistry & Applications

Electrospinning nanofiber containing disulfiram as anticancer treatment: Preparation, characterization and application

9^th Global Chemistry Congress

July 23-24, 2018 | Lisbon, Portugal

Gomaa F El Fawal

Scientific Research and Technological Applications City (SRTA-City) Egypt

Posters & Accepted Abstracts: Mod Chem Appl

Abstract:

Electrospinning is an efficient technique to produce ultrafine polymeric fibers. It has gained a great scientific and industrial interest due to its cost-efficiency, versatility and potential to be utilized in a wide range of applications. We used electrospinning to produce nanofibers from cellulose acetate (CA) and polyethylene oxide (PEO) polymers loaded with different concentrations of disulfiram (DS) for further implementing in anticancer treatment. Various tests were carried out including scanning electron microscopy (SEM), FTIR and thermal gravimetric analysis (TGA) to evaluate the efficiency of the prepared fibers as anticancer material. On the other hand, it revealed a potent apoptotic-dependent anticancer activity against human colon and breast cancer cells with minimal toxicity on human normal cells. Hence, the studied fiber was able to overcome one of the major existing obstacles for using DS as an anticancer drug by decreasing its toxicity against healthy cells. The current approach corroborated that PEO/CA nanofibers loaded by disulfiram could be applied as a promising safe candidate for anticancer treatment

Biography :

E-mail: gelfawal@gmail.com