Journal of Psychiatry

Effects of Inflammation Childhood Adversity and Psychiatric Symptoms on Brain Morphometric Phenotypes in Bipolar II Depression: Preliminary Exploration

European Conference on Psychiatry

March 09, 2023 | Webinar

Yuan Cao

West China Medical School of Sichuan University, China

Scientific Tracks Abstracts: J Psychiatry

Abstract:

The brain morphometric alteration in bipolar II depression (BDD) and its associations with inflammation childhood adversity and psychiatric symptoms are unclear. We studied the brain morphometric alteration of 150 BDD patients and 155 healthy controls (HCs) by using both VBM and SBM analysis to compare their neuroanatomical difference and to identify potential correlations with inflammation, childhood adversity and psychiatric symptoms by using partial Pearson correlation analysis. Compared with HCs the significantly different grey matter volumes (GMVs) were in front striatal and fronto-cerebellar area and insula recuts and temporal gyrus, and significantly cortical thickness differences were in frontal and temporal areas in BDD. Smaller GMVs in the right middle frontal gyrus, medial superior frontal gyrus, and insula were significantly correlated with server sexual and emotional abuse and total childhood adversity while thinner in left inferior temporal thickness were significantly correlated with server emotional neglect sexual and physical abuse and total childhood adversity in BDD. Higher inflammatory cytokines levels were significantly associated with lower GMVs in front striatal and fronto-cerebellar area, insula, and temporal gyrus and associated with thinner frontal areas thickness in BDD. We observed depressed and anxious moods would affect GMVs in the caudate and frontal and temporal gyrus. Unexpected positive relationships were found between psychotic symptoms and GMV. The abnormality of brain morphometric alteration in the front striatal and fronto-cerebellar area and insula recuts and temporal gyrus volumes and frontal-temporal thickness may reflect a core pathophysiological mechanism of BDD. These brain morphometric damages are affected by different degrees of involvement of inflammation, childhood adversity and psychiatric symptoms.

Biography :

Yuan Cao engaged in basic research on inflammatory factors activation in COPD at Nanchang University from 2015 to 2018. From 2018 to the present, she is focusing on firm research on neuropsychiatric illness. She is now a master-doctor medical student pursuing a Ph.D. At Sichuan University and engages in inflammatory-related neuropsychiatric imaging research especially in bipolar II depression.