Journal of Microbial & Biochemical Technology

Effect of Ofloxacin autogel on periodontopathic bacteria in chronic periodontitis

3^rd World Congress and Expo on Applied Microbiology

November 07-09, 2016 Dubai, UAE

Abeer S Gawish

King Abdulaziz University, KSA
Al-Azhar University, Egypt

Posters & Accepted Abstracts: J Microb Biochem Technol

Abstract:

An appreciated treatment modality for periodontitis is scaling and root planning followed by a controlled-release antimicrobial intra-pocket delivery system. The aim of the present work was to develop a smart controlled-release liposomal autogel system of ofloxacin and evaluate it for the management of aggressive periodontitis in adult patients. Autogels based on chitosan neutralized by β-glycerophosphate was prepared after setting a high degree of deacetylation for chitosan. The systems were characterized for mucoadhesion, syringeability and gelation onset. In vitro ofloxacin release in pH6.8 revealed about 83% release after 3 days. Further release modulation was done by encapsulation of ofloxacin in liposomes. Upon inclusion into the gel, liposomes afforded 80% of drug release in 7 days. When tested microbiologically in adult volunteers the ofloxacin liposomal autogel demonstrated markedly lower anaerobes bio-burden in sub-gingival plaque samples than ofloxacin solution after 7days. Moreover, the liposomal autogel formula showed significant improvement in the different clinical parameters evaluated. It can be concluded that the developed ofloxacin liposomal autogel is promising in the management of aggressive periodontitis in adults.

Biography :

Email: gawish27@gmail.com