Journal of Pharmacovigilance

Effect of Gymnema sylvestre on pharmacokinetics and pharmacodynamics of Pioglitazone in diabetic rats

3^rd International Conference and Exhibition on Pharmacovigilance & Clinical Trials

October 27-29, 2014 Hyderabad International Convention Centre, India

Shravan Kumar Dholi

YRF: J Pharmacovigilance

Abstract:

Effect of the Gymnema sylvestre (100 mg/kg and 500 mg/kg) on the pharmacokinetics and pharmacodynamics of (7.5 mg/kg and 10 mg/kg) Pioglitazone was studied in STZ induced six groups of hyperglycemic rats after single dose administration and multiple dosing for 21 days. Pharmacokinetic studies revealed a decrease in the bioavailability of pioglitazone when given in combination with Gymnema sylvestre. The decrease in bioavailability was contributed by decrease in absorption rate constant and increase in clearance whereas in the pharmacodynamic study the combination in general showed decrease in serum glucose, urea and cholesterol levels, which was contributed by the antidiabetic action of Gymnema sylvestre. But the combination of Gymnema sylvestre and Pioglitazone did not decrease the serum glucose, urea and cholesterol levels comparable to Pioglitazone when given alone. Histopathological studies revealed that combination of Gymnema sylvestre with pioglitazone increased the volume of islets cells of pancreas. These results indicates Gymnema sylvestre is potent hypoglycaemic but it contributes to a decrease in hypoglycemic influence of Pioglitazone. Results have indicated the negative influence of Gymnema sylvestre on pharmacokinetics but positive influence on pharmacodynamics of Pioglitazone.

Biography :

Shravan Kumar Dholi has completed M Pharm and pursuing PhD in JNTU, Kakinada. He has published more than 12 papers in national and international journals and presented more than 10 papers in national, international conferences.