Journal of Bioequivalence & Bioavailability

Design and evaluation of Olmesartan Medoxomil timed release dosage form to match the Circadian Rhythms of hypertension

3^rd World Congress Bioavailability & Bioequivalence

March 26-28, 2012 Marriott Hotel & Convention Centre, Hyderabad, India

J.N. Ravi Varma, S.A.Sunil, K. Sandhya, M.V. Srikanth and K.V. Ramana Murthy

Posters: J Bioequiv Availab

Abstract:

T he aim of this study was to develop chronotherapeutic drug delivery systems (ChDDS) of olmesartan medoxomil (OM) using hydrogenated castor oil (HCO) and hydrogenated vegetable oil (HVO) with a predetermined lag time of 6 hrs by compression coating technique. Solubility and in vitro dissolution of OM were increased by formulation of solid dispersions using novel carrier, sucrose fatty acid ester (SFE 1811) as the drug belongs to BCS class II with low solubility and high permeability. The optimized solid dispersion was formulated as immediate release core tablets which were further coated with HCO and HVO using compression coating technique. Different coat: core tablet weight ratios were tried out and as the coating polymers are of waxy nature, channeling agent (directly compressible lactose) was incorporated into coat to form pores on surface of coat to enhance penetration of dissolution media. Compression coated tablets (CCT) formulated with HCO in 1:1.5 and HVO in 1:1 ratio of core tablet weight and coating polymer were considered as optimized formulation, but CCT formulated with HVO was considered as final optimized formulation, as the desired lag time was obtained with less concentration of polymer. FTIR spectra indicated no interaction between drug and polymers used. As the developed ChDDS using compression coating technique is simple to prepare and can be easily scaled up with minor modifications of existing equipment and also in vitro lag time of 6 hrs obtained before immediate release of drug makes it a suitable formulation for treatment of hypertension which follows circadian rhythm