Health Care : Current Reviews

Control of D-glucose preserves renal function in patients with diabetes

3^rd Indo-Global Summit & Expo on Healthcare

October 05-07, 2015 New Delhi, India

Anil K Mandal

University of Florida, USA

Posters-Accepted Abstracts: Health Care: Current Reviews

Abstract:

We previously reported that D-glucose is a strong predictor of renal function change in diabetes. This study is an expansion of a previous study but with longer duration. Date compared between first and last visits. Eighty five diabetic patients were treated with a combination of glargine or detemir and regular or fast acting insulin for 26.3±24.6 (SD) months. Blood pressure was controlled by beta blockers, calcium channel blockers, sympathetic inhibitors or a combination and chlorthalidone in resistant cases. Angiotensin converting enzyme inhibitors and receptors blockers (ACEI/ARB) were excluded in order to reduce the risk of acute and chronic renal failure. Objectives were to determine if this paradigm of treatment prevents progression of diabetic nephropathy. Fasting (F) and 2-hour postprandial (2hPP), glucose, serum creatinine (Scr) and estimated glomerular filtration rate (eGFR); hemoglobin A1c (HbA1c) and sitting systolic and diastolic blood pressure (SBP) were recorded for first and last visits. Mean blood pressure (MBP) and differences (d, 2hPP-F) were calculated for glucose, Scr and eGFR. Parameters between first and last visits were compared using a paired t-test adjusted for age, gender and duration of treatment with P<0.05 considered significant. No significant differences were found between first and last visits for F and 2hPP glucose, F and 2hPP Scr and F and 2hPP eGFR and HbA1c. D-glucose, sitting SBP and MBP were significantly lower at last compared to first visit. Combining visits, D-glucose and HbA1c showed a direct and positive correlation with dScr. Change in post minus pre-treatment values was significantly positively correlated between HbA1c and FBG, 2hPPG or D-glucose. In conclusion, the current study emphasizes the importance of control of D-glucose (2hPP-F) with insulin in preserving renal function in diabetes when ACEI/ ARB is not used.

Biography :

Email: amandal@med-spec.com