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Characterization of mutations causing Rifampicin and Isoniazid resistance of Mycobacterium tuberculosis in Syria
3rd World Congress and Expo on Applied Microbiology
November 07-09, 2016 Dubai, UAE

Maya Habous

Dubai Health Authority, UAE

Posters & Accepted Abstracts: J Microb Biochem Technol

Abstract:

Aim & Objectives: In order to characterize mutations causing Rifampicin and Isoniazid resistance of M. tuberculosis in Syria. Methods: 69 rifampicin resistant (RIFr) and 72 isoniazid resistant (INHr) isolates were screened for point mutations in hot spots of the rpoB, katG and inhA genes by DNA sequencing and real time PCR. Results: Of 69 RIFr isolates, 62 (90%) had mutations in the Rifampin resistance determining region (RRDR) of the rpoB gene with codons 531 (61%), 526 (13%) and 516 (8.7%) being the most commonly mutated. We found two new mutations (Asp516Thr and Ser531Gly) described for the first time in the rpoB-RRDR in association with Rifampicin resistance. Only one mutation (Ile572Phe) was found outside the rpoB-RRDR. Of 72 INHr strains, 30 (41.6%) had a mutation in katG codon 315 (with Ser315Thr being the predominant alteration) and 23 (32%) harbored the inhA-15C

Biography :

Email: dr.mayah@yahoo.com

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