Journal of Pharmacovigilance

Cancer chemotherapy induced adverse drug reactions

4^th International Conference and Exhibition on Pharmacovigilance & Clinical Trials

August 10-12, 2015 London, UK

Shubhnita Singh and Deepti Chopra

Posters-Accepted Abstracts: J Pharmacovigilance

Abstract:

Background: Cancer chemotherapeutic drugs are associated with several adverse drug reactions. Thus, the present study was done to determine the prevalence of adverse events in patients treated with chemotherapy. Methods: Spontaneous ADR reports of patients on antineoplastic drugs were studied. These reports were analyzed for various carcinomas under treatment, medications used, types of ADRs, organ system involvement, severity, causality assessment and preventability. Results: Over a period of 2 years a total 591 cases were received. The prevalence of ADRs was more in female patients as compared to men. ADRs mostly occurred in the age group of 41-50 years (27.4%). Cisplatin (19.6%) was found to be the most common drug. The commonest ADR reported was nausea and vomiting. Gastroenterology (40.1%) was the most affected system. 12.9% ADRs were considered serious. Causality assessment revealed that 80% of the ADRs were possible. 86.97% cases were found to be mild and 51% were not preventable. Conclusion: Pharmacovigilance of these drugs needs to be explored and use of preventive measures needs to be enhanced in order to reduce the incidence and severity of ADRs.