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Bioactivity of Samsum ant (Pachycondylasennaarensis) venom against lipopolysaccharides through antioxidant and up-regulation of AKT1 signaling in rats
3rd International Congress on Bacteriology and Infectious Diseases
August 04-06, 2015 Valencia, Spain
Hossam EHussain, Mohamed Al-Khalifa, Ahmed M Isa and SaadGadoa
Posters-Accepted Abstracts: J Bacteriol Parasitol
Abstract:
Background: This study aimed at investigating the oxidative stress ameliorating effect, lipids profile restoration and the antiinflammatory
effect of Samsum Ant Venom (SAV) in induced endotoxemic male rats injected with bacterial lipopolysaccharides
(LPS).
Results: Results revealed that LPS significantly increased the oxidative stress indications in LPS-injected rats. A significant
increase of both malondialdehyde (MDA) and advanced oxidative protein products (AOPP) as well as a significant suppression
of glutathione were all detected. Treatment with 100 μg/kg dose of SAV significantly restored the oxidative stress normal
indications and increased the total glutathione levels. Treatment of the LPS-rats with 100 μg/kg dose of SAV showed a clear
anti-inflammatory function as the histological architecture of the hepatic tissue was partially recovered along with a valuable
decrease in the leukocytes infiltrated the hepatic tissues. Treatment of some rat groups with 600 μg/kg dose of SAV after LPS
injection induced a severe endotoxemia that resulted in very high mortality rates; SAV versus the effects of LPS on AKT1, Fas,
TNF-α and IFN-γ mRNA expression. SAV was found to significantly lower Fas gene expression comparing to the LPS group and
restore the level of IFN-γ mRNA expression to that of the control group.
Conclusion: In conclusion, SAV at the dose of 100 μg/kg body weight maintained and restored the oxidative stability, the antiinflammatory
and the hypolipidemic bioactivity in rats after induced disruption of these parameters by LPS injection. This
improvement by SAV was mediated by up-regulation of AKT1.