Shekari M, Sobti R C, Tamandani D M, Malekzadeh K, Kaur P and Suri V
Scientific Tracks Abstracts: J Bacteriol Parasitol
Cervical cancer is one of the most common neoplastic diseases affecting women with a combined worldwide incidence
of almost half a million new cases. Reduced DNA repair capacity (DRC) can render a high risk of developing many
types of cancer; including cervical cancer. Polymorphisms in DNA repair genes may contribute the genetic instability and
carcinogenesis. Smoking experience and use of oral contraceptives have been confirmed to be risk factors for cervical cancer.
The purpose of the present study was therefore to investigate APE-1 genotypes (Asp/Asp, Asp/Glu, Glu/Glu) with different
histological subtypes in cases compared with controls. It has been observed that Asp/Glu with Glu/Glu genotypes that combined
we observed statistically significant with protective effect for developing of cervix cancer (OR-0.51, 95% CI 0.31-0.83, p-0.006).
The combined Asp/Glu with Glu/Glu genotypes who were using oral contraceptives was shown to be statistically significant
with reduced risk of cervical cancer (OR-0.22 95% CI- 0.11-0.47, p-0.0002). It has been suggested that significantly correlation
between HPV 16 and users of oral contraceptives in certain APE-1 genotypes with reduced risk in developing cervix cancer. In
conclusion we observed statistical significant association with reduced risk of cervix cancer in APE-1 with different genotypes,
though on the other hand, in association between HPV type 18 and those having SCC highly increased the risk of cervical
cancer was observed.
Shekari M currently working as an Associated Professor at Department of Medical Genetics, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.