Health Care : Current Reviews

Anti-diabetic and anti-obesity potential of selected medicinal plants used in the traditional medicine of Jordan

4^th Asia-Pacific Global Summit & Expo on Healthcare

July 18-20, 2016 Brisbane, Australia

Fatma U Afifi, Violet Kasabri, Entisar Al-Hallaq and Simona C Litescu

The University of Jordan, Jordan
MSD Animal Health, Jordan
National Institute for Biological Sciences, Romania

Posters & Accepted Abstracts: Health Care Current Reviews

Abstract:

In the recent decades complementary/alternative/integrative medicine flourished and lead to the renaissance of nutritional, clinical and scientific interest in plants' potential as preventive/therapeutic agents in the management/treatment of chronic diseases. Worldwide and in Jordan the prevalence of type 2 diabetes (T2DM) and obesity has reached alarming proportions. Very big number aromatic, edible or medicinal plants are recommended in Jordan for the dual therapy of diabetes and obesity, referred to as diabesity. In the Jordanian traditional medicine Crataegus aronia and Adiantum capillus-veneris L. are two of the edible/medicinal plants used for the treatment of T2DM. The present study gives an overview of antidiabesity plants of Jordan and discusses the LC-MS evaluation of the crude extract, and in vitro and in vivo evaluation of different biological activities of A. capillus-veneris to evidence its claimed pharmacological potential. HPLC-MS analyses revealed the presence of ellagic acid (5.48 mg/g), rutin (4.77 mg/g), quercetin-3-O-glucoside (3.96 mg/g), ferulic acid (3.88 mg/g), gallic acid (3.44 mg/g), caffeic acid (1.55 mg/g), epicatechine (1.34 mg/g) and quercetine (0.43 mg/g) (Fig.1). Hypocholesterolemic efficacy was evaluated in 10-weeks high-cholesterol-diet (HCD) fed rats and compared to atorvastatin. A. capillus veneris aqueous extract (500mg/kg body weight [b.wt]) decreased highly significantly the total cholesterol (TC) and low density lipoproteins (LDL) in HCD-fed rats. Additionally, atherogenic index parameter of TC/HDL was normalized in A. capillus veneris -treated rats. Moreover, the plant extracts�?? and some of the identified constituents�?? role in modulating gastrointestinal carbohydrate and lipid digestion and absorption were demonstrated. The results indicate that A. capillus-veneris can be considered a potential candidate for the management of hypercholesterolemia, obesity and diabetes.

Biography :

Email: fatueafi@ju.edu.jo