Journal of Pharmacovigilance

Alprazolam potentiates analgesic effect of Ibuprofen in postendodontic pain

Conference Series LLC Joint International Event on 7^th Pharmacovigilance & Pharmaceutical Industry

August 22-24, 2016 Vienna, Austria

Mahmoud Baradaran, Mahmoud Reza Hamidi, Mohammad Reza Moghimi Firoozabad, Sohrab Kazemi, Manouchehr Ashrafpour and Ali Akbar Moghadamnia

Babol University of Medical Sciences, Iran

Posters & Accepted Abstracts: J Pharmacovigil

Abstract:

Postendodontic pain (PEP) has always been a major problem for patients and dentists and NSAIDs (Nonsteroidal anti-inflammatory drugs) are being used to relieve PEP and it is supposed that some benzodiazepines may potentiate the analgesic effects of NSAIDs. This study was conducted to evaluate the effect of alprazolam on the analgesic effect of Ibuprofen in PEP treatment. This randomized double-blind clinical trial was conducted on 45 patients aged 20-45 years who were subjected to root canal treatment. A written informed consent was obtained from each patient. The subjects were randomly divided into three groups; placebo, Ibuprofen (400 mg) and alprazolam (0.5) mg+Ibuprofen (400 mg). The intensity of pain was recorded using visual analog scale (VAS) at 4, 6, 12, 24, 48 and 72 hours after drug administration. Of the participants, twenty six (57.8%) were males and 19 patients (42.2%) were females. Four hours after starting the treatment, the VAS scores in the placebo and Ibuprofen-treated groups were significantly higher than Ibuprofen and alprazolam+Ibuprofen groups (p<0.0001). The VAS scores in alprazolam+Ibuprofen group (2.33±1.05) were significantly lower at 6 hours after treatment when compared to the other groups. The average pain score in female patients who received alprazolam+Ibuprofen was significantly lower than males at 12 hours (1.3±0.6 vs 2.14±0.9, P=0.002) and 24 hours after treatment (0.88±0.6 vs 1.86±0.9, P=0.003). It could be concluded that alprazolam may enhance the analgesic efficacy of Ibuprofen in postendodontic pain.

Biography :

Email: baradaran81@yahoo.com