Journal of Blood Disorders & Transfusion

Alloimmunization in Egyptian children with transfusion-dependent B thalassemia: A major challenge

7^th World Hematologists Congress

May 08-09, 2017 Barcelona, Spain

Nahla F Osman, Seham A Ragab and Mohamed A Soliman

Menoufia University Hospitals, Egypt

Posters & Accepted Abstracts: J Blood Disord Transfus

Abstract:

Aim: B thalassemia is a common health issue in Egypt. However, few national studies were carried out to address the problem of alloimmunization and common alloantibodies in multi-transfused thalassemia patients. This study was designed to address those issues with the aim of optimizing the management in those patients. Methods: The study included 281 multi-transfused B thalassemia Egyptian children from Delta region. Antibody screening and identification were carried out using column agglutination technology. Results: 67 patients (23.8%) were found to have alloantibodies. Anti-kell and anti E were the most commonly encountered antibodies seen in 37.3% and 34.3% of patients, respectively. There was no significant difference in alloimmunization rate between males and females or between patients with thalassemia major and intermediate. Conclusion: Alloimmunization is seen in nearly quarter of multi-transfused B thalassemia patients. Development of RBCs antibodies is multifactorial; however, a significant proportion of those can be prevented if pre-transfusion testing involved cross matching for the most immunogenic minor RBCs antigens. Although this would increase the upfront cost, the long term cost is likely to fall and is likely to improve patientsâ?? management.

Biography :

Email: nahlaos@yahoo.com