Journal of Bacteriology & Parasitology

Advancements in Understanding Osteomyelitis in Diabetes mellitus: Insights into Pathophysiology and Therapeutic Approaches

19^th World Conference on Infectious Diseases, Prevention and Control

December 10-11, 2024 | Dubai, UAE

Mohammad Nadeem Khan, Ashok Kumar

Department of Pharmacology, Sri Aurobindo Medical College & PG Institute, Indore

Scientific Tracks Abstracts: J Bacteriol Parasitol

Abstract:

Osteomyelitis poses a significant clinical challenge, particularly in patients with hyperglycemic disturbances such as diabetes mellitus. This systematic study examines recent progress in comprehending the pathophysiological mechanisms underlying osteomyelitis in the context of hyperglycemia and explores emerging therapeutic strategies. Hyperglycemia exacerbates the severity and progression of osteomyelitis through multifaceted mechanisms. Impaired host immune responses, including compromised leukocyte function and deregulated inflammatory pathways, contribute to increased susceptibility to bone infections. Moreover, elevated glucose levels create a favorable environment for microbial proliferation and biofilm formation within bone tissue, promoting chronicity and treatment resistance. Concurrent alterations in bone metabolism and microvascular function further complicate the pathogenesis of osteomyelitis in hyperglycemic individuals. Therapeutic approaches for osteomyelitis management in hyperglycemic patients have evolved to address these complex interactions. Antibiotic therapy, guided by antimicrobial susceptibility testing and biofilm-targeting agents, remains a cornerstone of treatment. Surgical interventions, such as debridement and bone grafting, are essential for removing infected tissue and restoring bone integrity. Adjunctive therapies, including hyperbaric oxygen therapy and immunomodulatory agents, hold promise in enhancing treatment efficacy and reducing recurrence rates. Recent advancements in diagnostic techniques, such as molecular imaging and biomarker profiling, offer opportunities for early detection and monitoring of osteomyelitis in hyperglycemic individuals. Personalized therapeutic strategies, tailored to patient-specific factors and microbial profiles, may further optimize treatment outcomes and minimize complications. In hyperglycemic disturbance has provided valuable insights into novel therapeutic targets and approaches. Continued research efforts are necessary to refine diagnostic modalities, develop targeted therapies, and improve clinical outcomes in this challenging patient population. Key words: Osteomyelitis, Hyperglycemia, Antibiotic resistance, Immune response, Antibiotic therapy, Surgical interventions ,Hyperbaric oxygen therapy, Biomarkers, Molecular imaging, Personalized medicine

Biography :

Mohammad Nadeem Khan is a distinguished academic and researcher in the field of pharmacology, currently affiliated with the Department of Pharmacology at Sri Aurobindo Medical College & PG Institute, Indore. His work focuses on advancing medical knowledge and therapeutic strategies, particularly in the areas of infectious diseases, diabetes-related complications, and drug therapies.