Journal of Stem Cell Research & Therapy

Adherence to hydroxyurea therapy in patients with sickle cell disease at King Khalid University Hospital in Riyadh

5^th International Conference and Exhibition on Cell and Gene Therapy

May 19-21, 2016 San Antonio, USA

Meshaal, Bakrman A K, Alzahrani A M, Alotaibi M S, Bin Salamah A A, AlHejjei S A and Al-Anazi K A

King Saud University, Saudi Arabia

Scientific Tracks Abstracts: J Stem Cell Res Ther

Abstract:

Background: Sickle cell disease is associated with several systemic complications and life-threateningcrises. The use of drugs that increase hemoglobin F level, such as hydroxyurea, in patientswith sickle cell disease is associated with a reduction in the severity of the disease. Aim: To compare the outcome of patients adherent to hydroxyurea with those who are poorly adherent and to determine which age group is more likely to be poorly adherent and hence suffer more complications. Subjects & Methods: A cross-sectional study was performed at King Khalid University Hospital in Riyadh between January 01 and March 31, 2014. The study included 140 patients, 60 of them were receiving hydroxyurea therapy. Results: Patients who were adherent to hydroxyurea treatment suffered less complications and had lessfrequent sickling crises than patients who were poorly adherent to therapy. Patients belonging to the age group 15 to 30 years were found to be less adherent to treatment than other age groups and consequently they suffered more complications. Conclusion: More attention and health education should be offered to adolescents and young adults having sickle cell anaemia in order for these patients to benefit from the positive impact of hydroxyurea on the disease outcome.

Biography :

Meshaal pursuing Research and currently working in the King Saud University located at Saudi Arabia.

Email: Dr.1m@hotmail.com