Journal of Bacteriology & Parasitology

A serological investigation of infections in the etiology of schizophrenia, Cukurova Region, Turkey

3^rd International Congress on Bacteriology and Infectious Diseases

August 04-06, 2015 Valencia, Spain

Mahdi Marzi, Tulin Guven Gokmen, Begum Kayar, Farzad Heydar and Fatih Koksal

Posters-Accepted Abstracts: J Bacteriol Parasitol

Abstract:

Introduction: Schizophrenia is a chronic, severe and disabling brain disorder that affects approximately 1% of the world’s
population and the underlying mechanisms are not thoroughly understood. Recent studies supporting the hypothesis that
infections especially Syphilis, Brucellosis, Chlamydiosis, Toxoplasmosis, Herpes Simplex Virus (HSV), Cytomegalovirus
(CMV) and Bornavirus can cause psychiatric syndromes when they infect adults is well known and plays a role in the etiology
of schizophrenia is increasing.
Aim: This study aimed to investigate relationships between various infections and schizophrenia in Cukurova region of Turkey.
Materials & Methods: A total of 172 patients with schizophrenia and 100 healthy individuals as controls attending Cukurova
University Hospital and Adana Mental and Neurological Diseases Hospital who fulfilled the (DSM-IV) criteria were re¬cruited
in this study. All collected serums were analysed in terms of IgG levels of Chlamydia spp, T. pallidum, T. gondii, HSV1, HSV2,
CMV and Bornavirus with ELISA.
Results: The results of patients and control group samples for CMV, HSV1, HSV2, T. gondii, T. pallidum, C. trachmatis, C.
pneumonia and Bornavirus by EIA were 93%, 98%, 58%, 91%, 85%, 3%, 80%, 4% and 92%, 96%, 58%, 68%, 0%, 8%, 63%, 0%
respectively.
Conclusions: Our findings showed that there were significant differences between seropositivity of T. gondii, C. pneumoniae,
Bornavirus IgG antibodies among patients with schizophrenia compared to controls, suggesting the important role of infections
in schizophrenia.