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A common spice prevents liver cancer lesions: Bioinformatics and network analyse
Joint Meeting on 13th World Congress on Industrial Healthcare and Medical Tourism & 2nd World Congress on Bioinformatics & System Biology
October 15-16, 2018 Dubai, UAE
Amr Amin
United Arab Emirates University, UAE
Keynote: Health Care Current Reviews
Abstract:
The multi-kinase inhibitor, sorafenib, remains for a decade now the fi rst and only systemic therapy for the treatment of Hepatocellular Carcinoma (HCC). Th us, a novel approach against HCC is essential for a better therapeutic outcome. Th e aims of this study is to assess the chemo-preventive action of Saff ron??�????????s main biomolecule, crocin, against chemically-induced liver cancer in rats and to explore the mechanisms by which crocin employs its anti-tumor eff ects. We provide a network analysis of diff erentially expressed genes in tissues of animals pre-treated with crocin in comparison to induced-HCC animals??�???????? tissues. To further support our results, we assessed the eff ects of crocin on HepG2 cells viability by treating them with various concentration of crocin; in addition, eff ects of crocin on cell cycle distribution of HepG2 cells were investigated. Network analysis identifi ed NF-kB as a potential regulatory hub and therefore, a candidate therapeutic drug target.
Biography :
Amr Amin has completed his PhD at University of Illinois at Chicago and received a Post-Doctoral training in the eld of Molecular Genetics at University of Pennsylvania School of Medicine. He started his academic career at UAE University where he serves currently as a full Professor of Cell and Molecular Biology. His research focuses on ways to control cancer, particularly liver cancer. He has published many research articles, reviews and serves as ad hoc Reviewer and as an Editorial Member of many specialized peer-reviewed journals. He is also a member of many specialized societies and the sole recipient of many national and international scienti c awards; Khalifa Award for Research being the most recent.
E-mail: a.amin@uaeu.ac.ae