Journal of Nanomedicine & Nanotechnology

Toxicity of Nanoparticles that have been created so far: A Review

Kevin Jacobs^* Department of Pharmacy, UCL College of Pharmacy, London, United Kingdom
^*Correspondence: Kevin Jacobs, Department of Pharmacy, UCL College of Pharmacy, London, United Kingdom, Email:

Received: 05-Jan-2022, Manuscript No. jnmnt-22-15972(PQ); Editor assigned: 07-Jan-2022, Pre QC No. jnmnt-22-15972(PQ); Reviewed: 14-Jan-2022, QC No. jnmnt-22-15972; Revised: 17-Jan-2022, Manuscript No. jnmnt-22-15972(R); Published: 24-Jan-2022, DOI: 10.35248/2157-7439.1000600

Introduction

Nanomaterial’s that have been manufactured and have unique qualities have been widely used in a variety of industries, agriculture, and medicine. Some of the features, however, have been linked to the toxicity of nanomaterials. Concerns over the use and growth of nanotechnology have arisen as a result of the "nano-paradox," making it difficult for regulatory authorities to regulate nanomaterials. The ability to comprehend the impact of nanomaterial qualities on Nano-bio interactions is crucial to proper nanomaterial regulation. To that purpose, we begin by giving a quick overview of Nano-bio interactions at various levels [1]. The impact of key toxicity-related properties of manufactured nanomaterial’s (i.e., size, shape, chemical composition, surface properties, bio corona formation, agglomeration and/or aggregation state, and biodegradability) on toxic kinetics, cellular uptake, trafficking, and responses, as well as toxicity mechanisms, is investigated in depth. Advanced analytical methods for analysing Nano-bio interactions are also discussed. The current regulatory and legislative frameworks for nanomaterialcontaining products in various areas and/or nations are also discussed. Finally, in order to shed light on the safety evaluation of nanomaterial’s, we offer numerous issues facing the area of Nano toxicology and possible solutions. Nanomaterial’s or Nano-enabled goods have seen rapid growth and widespread use in a variety of industries, including energy, aerospace, agriculture, industry, and biology, over the last few decades. Despite nanotechnology's great contributions to human society, there is still widespread concern about nanomaterial toxicity in a variety of organisms, from environmental species to humans. Nano toxicology is the study of the harmful effects of nanomaterial’s or Nano products on living creatures over the course of their lives, with the goal of ensuring reliable safety assessments and adequate regulation of nanomaterial manufacture, usage, and deposition. Obtaining a thorough understanding of the underlying toxicological knowledge of nanoparticles is a precondition for achieving these objectives. Nano toxicological research aims to better understand how nanomaterial’s interact with organisms at the organ/tissue, cellular, and molecular levels, with a focus on toxic kinetics (absorption, distribution, metabolism, excretion (ADME)), cellular uptake and trafficking, toxicity, and underlying mechanisms [2]. Interactions between nanotechnology and biology at the organ, cellular, and molecular levels: Humans can be exposed to manufactured nanomaterials at various times of their lifecycles and for various purposes, such as pulmonary inhalation, oral uptake, skin contact, and intravenous injections, among other methods. Various nanomaterial transformations, such as aggregation/agglomeration, dissolution, and the formation/evolution of bio corona, can occur at their entrance portals, affecting their toxic kinetics and biological consequences. The bulk of Nano products inhaled, orally ingested, and topically applied to the skin become lodged in complicated bio environments and end up in the exposed organs, where they might cause further harm before being eventually removed out of the body. While a small percentage of these nanomaterial’s can be absorbed into the blood and/or lymphatic system, the majority cannot. Nonintravenously injected nanomaterial’s have a more broad and even dispersion over the body because to the delayed dosage rate, unique absorption routes, and distinctive biocorona acquired/evolved, as well as their migration from exposure portals to absorption sites. Intravenously injected equivalents, on the other hand, are swiftly removed from the bloodstream and accumulate mostly in MPSrich tissues like the liver and spleen. Furthermore, circulating nanomaterial’s may penetrate the blood-brain barrier, blood-testis barrier, and placental barrier to reach the central nervous system, reproductive system, and progeny, and have biological effects on these organs, regardless of the source of exposure. Nanomaterial’s have different breakdown, metabolism, and excretion patterns depending on their characteristics, which primarily occur in the liver and kidney. Nanomaterial’s can potentially target a range of organs, including the lung, intestine, liver, spleen, and kidney, according to their toxic kinetic process [3]. Inflammation, granulomas, and fibrosis of the lungs, gut and micro biota dysfunction, liver damage and malfunction, spleen inflammation, and kidney injury are all examples of pulmonary toxicity. Following that, Nano-bio interactions [4] at the cellular, subcellular, and molecular levels provide more fundamental reasons for organ/tissue toxicity as well as helpful guidelines for nanomaterial safety assessment. Membranes can bind to, pierce through, embed in, and/or internalise nanomaterial’s in general. Nanomaterial’s can be internalised by cells in a variety of ways, affecting their intracellular location, destiny, and cytotoxicity in the process. The chemical nature of core nanomaterial’s, impurities, functionalization techniques, surface qualities (surface charge/hydrophobicity/ligands), size, shape, agglomeration, and bio corona are all factors that influence Nanobio interactions at various levels. Despite significant advances in the science of Nano toxicology, determining the safety of various nanomaterial’s remains a daunting task. As previously said, a wide range of nanomaterial physicochemical features can work with or against one another to produce complex effects at various levels of Nano-bio interactions. Because of the overlapping impacts of numerous nanomaterial qualities on diverse toxicological processes, validating the causal linkages between ultimate Nano toxicity and nanomaterial physicochemical properties is extremely difficult. To this purpose, careful material design and accurate production of nanomaterial’s, which provides a library of nanomaterial’s with only one different property from each other yet encompassing a large range of properties of interest, is highly valued and urgently required. Furthermore, many toxicological researches ignore realistic conditions of Nano toxicity induction, resulting in the investigation of exaggerated Nano toxicity pathways [5].

REFERENCES

1. Pawelczyk E, Arbab AS, Chaudhry A, Balakumaran A, Robey PG, Frank JA. In vitro model of bromodeoxyuridine or iron oxide nanoparticle uptake by activated macrophages from labeled stem cells: implications for cellular therapy. Stem cells. 2008; 26:1366â??1375.

Indexed at, Google Scholar, Crossref

2. Ge Y, Zhang Y, He S, Nie F, Teng G, Gu N. Fluorescence modified chitosan-coated magnetic nanoparticles for high-efficient cellular imaging. Nanoscale research letters. 2009; 4:287â??295.

Indexed at, Google Scholar, Crossref

3. Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiestl RH. Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer research. 2009; 69:8784â??8789.

Indexed at, Google Scholar, Crossref

4. Bhattacharya K, Davoren M, Boertz J, Schins R, Hoffmann E, Dopp E. Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells. Partical and fiber toxciology. 2009; 6:17.

Indexed at, Google Scholar, Crossref

5. Liu H, Ma L, Zhao J, Liu J, Yan J, Ruan J, et al. Biochemical toxicity of nano-anatase TiO2 particles in mice. Biological trace element research. 2009; 129:170â??180.

Indexed at, Google Scholar, Crossref