Journal of Thrombosis and Circulation: Open Access

Thrombus Burden and Foretell Intracranial Hypertension in Cerebral Venous Sinus Thrombosis

Rautou Obispo^* Department of Pharmacy, Mujib Medical University, Dhaka, Bangladesh
^*Correspondence: Rautou Obispo, Department of Pharmacy, Mujib Medical University, Dhaka, Bangladesh, Email:

Received: 02-Jan-2023, Manuscript No. JTCOA-23-19772; Editor assigned: 04-Jan-2023, Pre QC No. JTCOA-23-19772 (PQ); Reviewed: 18-Jan-2023, QC No. JTCOA-23-19772; Revised: 25-Jan-2023, Manuscript No. JTCOA-23-19772 (R); Published: 02-Feb-2023, DOI: 10.35248/ 2572-9462.23.9.204

Description

Patients with severe CVST are known to be more susceptible to intracranial hypertension and visual impairment. The brain damage caused by CVST may be exacerbated by severe and ongoing cerebral venous outflow blockage and the ensuing intracranial hypertension. Although the majority of patients with CVST were functionally independent as measured by the Modified Ranking Scale (MRS) during long-term follow-up, a significant portion of them still had a series of persistent neurologic sequelae, such as severe residual headache, neuropsychological issues, and long-term visual disorder, which prevented them from going back to their previous jobs and may have been related to the significant residual neurological damage. Therefore, assessing the severity and therapeutic responses of CVST might benefit from continuous monitoring of the thrombus burden and ICP. To calculate the thrombus burden of CVST, prior methods, however, only described the location of thrombi and roughly assessed the thrombus burden at each sinus with a binary scoring rule, which might have overlooked some significant features due to the limited imaging techniques available at the time. Additionally, frequent lumbar punctures for ICP monitoring are dangerous and unethical, particularly in patients who are taking anticoagulant therapy and have severe intracranial hypertension. Therefore, a non-invasive approach to assess the thrombus burden and ICP in CVST is needed to track the progression of the disease and direct further treatment. To this study knowledge, however, there has never been a score system like this developed before, which could contain the dual functions at the same time. By efficiently suppressing blood signals, MRBTI, a T1-weighted imaging technique, could directly view the thrombus and had the capacity to measure thrombus volume, which was widely employed to diagnose CVST. However, thrombus volume estimation on MRBTI maps needed the time-consuming and laborious post-imaging processing, which was not appropriate for emergency evaluation in the clinical context. In order to facilitate the emergency evaluation in clinical practice, sought to propose a thorough and semi-quantitative scoring method based on MRBTI that took into account a number of factors, including the segmentation of thrombi, the thrombus burden at each segment, and the dominance of the transverse sinus. It would also look into the relationship between the score and ICP to see if it could be used to monitor ICP noninvasively during routine follow-up, and would compare the novel CVST-ability Score's to diagnose intracranial hypertension with two other traditional scoring techniques that have been applied in recent clinical studies. In this investigation, developed a unique CVSTScore based on the MRBTI sequence to semi-quantitatively assess the thrombus load, which was closely associated to the ICP, demonstrating its potential to predict intracranial hypertension noninvasively. It is discovered a link between CVST-Score and ICP since the CVST-Score in the high ICP subgroup was considerably greater than that in the normal ICP subgroup. A univariate linear regression was conducted to further confirm the outcome, and the results showed that in patients with ICP 330mm H2O, CVST-Score was linearly and positively linked with ICP, indicating that CVST-Score may be used to monitor ICP noninvasively during routine follow-up. In order to quantify the thrombus burden of CVST comprehensively without relying on the laborious and timeconsuming post-imaging analysis, this study presented a novel and patient-specific CVST-Score based on MRBTI. When compared to other traditional approaches, the innovative score demonstrated higher diagnostic performance for intracranial hypertension. Additionally, after controlling for confounders, the CVST-Score showed a strong and positive correlation with ICP, indicating the possibility of using it to noninvasively predict intracranial hypertension. This finding may contribute to the development of a specialized method to assess the severity and therapeutic outcomes of CVST and prevent needless invasive procedures during long-term follow-up.