Lessons Learned from Two Missed Prenatal Cases of Hemoglobin Barts Hydrops Fetalis Until Second Trimester Despite a Nationwide Screening Program

Wu WJ^1,2#, Ma GC^1,3#, Wu PC⁴, Huang KS⁵, Liu YL⁵, Chang SP¹, Ginsberg NA⁶ and Chen M^1,2,7,8*

¹Department of Genomic Medicine, and Department of Genomic Technology and Science, Changhua Christian Hospital, Changhua, Taiwan

²Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan

³Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan

⁴Taiji Fetal Medicine Center, Taipei, Taiwan

⁵Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

⁶Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University Medical Center, Chicago, IL, USA

⁷Department of Obstetrics and Gynecology, College of Medicine, and Hospital, National Taiwan University, Taipei, Taiwan

⁸Department of Life Science, Tunghai University, Taichung, Taiwan

^#Contributed equally to this work