Effect of a Dietary Supplement Containing Raspberry Ketone on Cytochrome P450 3A Activity

Masayuki Sekizuka^1#, Jing Wei Qi^2#, Tohru Aomori^2,3,4, Yuko Okada¹, Katsunori Nakamura⁵, Takuya Araki^2,3, Ryuya Horiuchi², Shin Ohta⁶, Tomonori Nakamura^2,3 and Koujirou Yamamoto^2,3*

¹Faculty of Pharmacy, Takasaki University of Health and Welfare 37-1 Nakaoorui-machi, Takasaki, Gunma 370-0033, Japan

²Department of Clinical Pharmacology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan

³Department of Pharmacy, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan

⁴Center for Medical Education, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan

⁵Educational Research Center for Clinical Pharmacy, Nagoya City University Graduate School of Pharmaceutical Sciences, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan

⁶Department of Pharmaceutical Health Care and Science, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachiouji, Tokyo 192-0355, Japan

^#Contributed equally to this work