Journal of Bioequivalence & Bioavailability

Comparative Bioavailability Study of Ultra Q 300 and COQ300 Coenzyme Q10 in Healthy Adults.

SM Rahman¹, Honey Qureshi¹, Poorneshwar Sawant², Sunil Kulkarni², Ravindra Mote^3* and Parikshit Champanerkar^{3 1}Departement of Fertility, Cradle Fertility Centre, Kolkata, India
²Department of Medicine, Meyer Organics Private Limited, Maharashtra, India
³Department of Bioanalytical, Bio-Prospera Clinical Research Pvt. Ltd, Maharashtra, India
^*Correspondence: Ravindra Mote, Department of Bioanalytical, Bio-Prospera Clinical Research Pvt. Ltd, Maharashtra, India, Email:

Received: 01-Dec-2025, Manuscript No. JBB-25-30444; Editor assigned: 03-Dec-2025, Pre QC No. JBB-25-30444 (PQ); Reviewed: 17-Dec-2025, QC No. JBB-25-30444; Revised: 24-Dec-2025, Manuscript No. JBB-25-30444 (R); Published: 31-Dec-2025

Keywords

Coenzyme Q10; Bioavailability; Safety; Healthy volunteers; Pharmacokinetic parameters

Introduction

Every human cell contains Coenzyme Q₁₀ (CoQ₁₀), also known as ubiquinone or ubidecarenone, a fat-soluble, vitamin-like molecule which emphasizes its widespread distribution. Although it is mostly found in the mitochondria, it is also found in cell membranes and is transported into the bloodstream via lipoproteins [1]. CoQ₁₀ is a strong antioxidant that protects cells from oxidative damage when it is reduced to ubiquinol [2]. It functions as a coenzyme for mitochondrial complexes I, II, and III, which are in the role of synthesizing Adenosine Triphosphate (ATP), which is responsible for around 95% of the energy produced by the cell. Because free radicals are commonly produced in the inner mitochondrial membrane, CoQ₁₀'s antioxidant activity is crucial there. It also promotes antioxidant protection in plasma membranes [3].

In the United States, CoQ₁₀ is available over the counter as a dietary supplement, as it may help boost the production of key antioxidants like superoxide dismutase-an enzyme that plays an important role in reducing vascular oxidative stress, particularly in people with high blood pressure. Additionally, CoQ₁₀ helps decrease lipid peroxidation by reducing the presence of harmful pro-oxidant substances. By improving blood circulation and safeguarding blood vessels by preserving nitric oxide, it also promotes cardiovascular health [4,5].

The body naturally produces CoQ₁₀, and it is found in highest concentrations in organs that require significant energy, including the heart, kidneys, liver, muscles, pancreas as well as thyroid gland. However, CoQ₁₀ levels in these tissues tend to decrease with age [6]. Although it is found in some foods, such as meat and fish, the dietary amounts are relatively limited. Therefore, many nutrition experts consider CoQ₁₀ a valuable option for supplementation [7].

CoQ₁₀ is a fat-soluble compound with a large molecular weight, which leads to slow and limited absorption. However, its uptake improves when consumed with fatty foods. After ingestion, the levels in the blood are usually reached between 5.8 and 8.1 hours, and it has a long half-life of over 30 hours. The bioavailability of CoQ₁₀ depends on its formulation-solubilized forms like ubiquinol, liposomes, nano-capsules, and nanoemulsions are absorbed more efficiently. Once absorbed in the small intestine, CoQ₁₀ is converted into its active form, ubiquinol, transported to the liver, and then released into the bloodstream via VLDL and LDL particles. It tends to accumulate in energy-demanding tissues such as the heart, liver, and muscles, highlighting its essential role in mitochondrial energy production. A second peak in blood levels may occur due to enterohepatic recycling, and the compound is mainly eliminated through bile and feces [4,8]

Coenzyme Q₁₀ (CoQ₁₀) supplementation underscores its essential role in supporting cellular energy production and protecting against oxidative stress. Numerous illnesses, such as metabolic, mitochondrial, neurological, and cardiovascular problems, have been connected to low levels of CoQ₁₀. Taking CoQ₁₀ as a supplement is generally regarded as safe and may help improve symptoms in several conditions, such as fibromyalgia, diabetes, cancer, and age-related diseases [9].

While CoQ₁₀ is naturally found in the human body and is typically well-tolerated, occasional mild side effects have been observed, such as loss of appetite, nausea, vomiting, diarrhea, indigestion, dizziness, and headaches. Less common side effects include light sensitivity, irritability, heartburn, increased involuntary movements, and fatigue. In some cases, individuals taking 300 mg or more per day may experience elevated liver enzymes, though no evidence of liver toxicity has been reported. An early study suggested a potential interaction with warfarin; however, subsequent controlled research did not support this finding. People with bile duct obstruction should use CoQ₁₀ with caution [4,8].

CoQ₁₀ deficiency is associated with cardiomyopathies as well as degenerative diseases affecting muscles and nerve cells. Key clinical manifestations of CoQ₁₀ deficiency include encephalomyopathy, severe infantile multisystem disorders, cerebellar ataxia, and leigh syndrome accompanied by growth delays, ataxia with hearing loss, and isolated muscle disorders. The most severe forms of CoQ₁₀ deficiency in humans result from autosomal recessive mutations. These deficiencies are categorized as primary when the mutations directly impact genes involved in CoQ₁₀ biosynthesis, or as secondary when they arise from other underlying genetic abnormalities [10].

Supplementation with Coenzyme Q₁₀ (CoQ₁₀) has been shown to consistently reduce oxidative stress and muscle damage, which promotes a quicker recovery from exercise. Nevertheless, it usually has a limited and erratic effect in enhancing aerobic performance. CoQ₁₀ seems to be more helpful for recuperation than for improving overall athletic performance, even if some benefits have been observed in anaerobic or high-intensity activity [11].

Studies on Coenzyme Q₁₀ (CoQ₁₀) and its effects on exercise suggest that supplementation reliably lowers oxidative stress and muscle damage, which supports faster recovery. However, its impact on boosting aerobic performance is limited and varies between individuals. Although some improvements have been noted in anaerobic or high-intensity exercises, CoQ₁₀ is generally more beneficial for recovery than for directly enhancing athletic performance [12].

Coenzyme Q₁₀ (CoQ₁₀) protects against oxidative damage and increases mitochondrial generation of energy, which helps control neurological disorders. It works most effectively in cases of primary CoQ₁₀ deficiencies and is generally safe and welltolerated. Clinical outcomes have been inconsistent, despite experimental research suggesting potential benefits for diseases like Parkinson's, Alzheimer's, and ALS. Consequently, CoQ₁₀ is regarded as a promising supportive therapy; nevertheless, further research is required to verify its efficacy in humans [13].

A meta-analysis of six studies including 1,529 women with diminished ovarian reserve revealed that CoQ₁₀ supplementation prior to IVF/ICSI enhanced pregnancy rates, increased the number of retrieved oocytes, improved embryo quality, and positively influenced hormone levels. Additionally, it was associated with lower miscarriage rates and reduced medication usage. However, CoQ₁₀ did not impact endometrial thickness [14].

Review of 11 small studies examining Coenzyme Q₁₀ in heart failure revealed limited and inconsistent evidence. CoQ₁₀ might help lower mortality rates, reduce hospitalizations, and improve certain symptoms such as NYHA classification and 6-minute walk distance. However, its impact on heart function Left Ventricular Ejection Fraction (LVEF), exercise capacity, and overall symptom scores was minimal or uncertain. Due to significant variability in the data, results could not be combined, and most studies had short follow-up periods and small participant numbers. Overall, more rigorous, high-quality research is necessary to confirm the potential benefits of CoQ₁₀ in heart failure [15].

As oxidative stress, inflammation, and mitochondrial function are significant contributors in autoimmune illnesses, Coenzyme Q₁₀ (CoQ₁₀) has shown promise in managing these medical conditions. According to studies, CoQ₁₀ may help reduce the symptoms of conditions like multiple sclerosis, fibromyalgia, lupus, and rheumatoid arthritis. Although the results are promising larger, more reliable clinical trials are required to confirm its efficacy, as the majority of current research is based on small-scale investigations [16].

A six-month study involving 60 patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MDASLD) demonstrated that high-dose CoQ₁₀ decreased liver fat accumulation and enhanced vascular, endothelial, and heart functions, while also reducing blood pressure. These findings indicate that CoQ₁₀ could help lower cardiovascular risk in MASLD patients with few side effects [17].

The objective of this study was to compare and evaluate the absorption rate and total bioavailability of the test formulation of Ultra Q 300 (Coenzyme Q₁₀) capsules with the reference formulation of other brand having similar composition (Coenzyme Q₁₀) capsules. Evaluating the safety and tolerability of a single Ultra Q 300 dosage in healthy adult volunteers while they were fasting was a secondary goal.

Materials and Methodology

Study materials

The test formulation, Ultra Q 300 (Co-enzyme Q₁₀) capsules, was supplied by Meyer Organics Pvt. Ltd., 300 mg, while the reference formulation, other brand having similar composition (Co-enzyme Q₁₀) capsule, and 300 mg. All study drugs were offered by Meyer Organics Pvt. Ltd.

Subjects

The study recruited fourteen (14) healthy adult volunteers. Routine laboratory tests, clinical examinations, vital sign assessments, ECG recordings, and urinalysis results were all normal for each subject. The following individuals were not permitted to participate: (i) subjects who have a history or are currently suffering from of any condition affecting the hematopoietic, renal, hepatic, endocrine, pulmonary, central nervous, cardiovascular, immune, dermatological, gastrointestinal, or other body systems; (ii) people who have taken any medication, whether prescribed, over-the-counter, or herbal remedies, within 14 days prior to dosing in period I, or who have received any vaccinations during that time; (iv) people who have a history or present of asthma (including aspirininduced asthma), nasal polyps, or NSAID-induced urticarial; (v) participants who were enrolled in current investigations at the beginning of the experiment or who had taken part in other clinical trials within the previous ninety days; and (vi) women who were pregnant or expected to become pregnant. The Shah Lifeline Hospital and Heart Institute Pvt. Ltd. Ethics Committee in Thane, Maharashtra, granted its approval to the study protocol.

Study Design

The declaration of helsinki and good clinical practice criteria were followed in the study protocol. Participants received comprehensive information about the study's objectives, methods, possible risks, advantages, and potential adverse drug reactions prior to recruitment. Every participant provided their written informed consent and voluntarily consented to participate in study. Every participant has undergone a thorough screening procedure. Anyone who met the exclusion criteria was not allowed to participate in the study, but those who met the criteria for inclusion were.

Healthy adults between the ages of 18 and 45 who had a BMI between 18.5 and 29.9 kg/m² participated in the bioavailability trial. Participants that were male weighed at least 50 kg. Two equal groups of participants were assigned to receive the test medication, Ultra Q 300, and the reference medication, other brand having similar composition. According to the schedule, patients received a 300 mg dosage of either Ultra Q 300 or other brand having similar composition on the first day of each dosing period after fasting for at least 10 hours the night before. The dose intervals were separated by a 15-day washout period.

All subjects fasted for at least 10 hours before intake of Coenzyme Q₁₀ and for an additional 4 hours following dosing throughout each dosing interval. 240 milliliters of water were administered to take the doses. Water consumption was restricted for one hour prior to and one hour following dosage, but otherwise unrestricted. After receiving their doses at the scheduled times, participants were instructed to remain seated for the first two hours.

Sample size

The bioavailability of Ultra Q 300 and other brand having similar composition was compared in an open-label, randomized, balanced, two-treatment, two-sequence, two-period crossover, single-dose oral bioavailability study. The Coefficient of Variation (CV%) for Coenzyme Q₁₀ Cmax was calculated to be between 28% and 32% based on data from earlier studies [18,19]. The study's estimated sample size was 14 participants, based on a β value of 20% (power=80%), an α level of 0.05, and a bioequivalence margin (θ) of 0.95-1.05.

Pharmacokinetic analysis

Blood samples were drawn from participants at 25 specific time intervals for Pharmacokinetic (PK) study. Five milliliters (5 ml) of blood were drawn within two minutes of the scheduled time for pre-dose samples (at -1.00 and -0.50 hours), and five minutes before the drug was administered in each research period for the 0.00-hour pre-dose sample. Post-dose samples were collected at the following intervals: 1.00, 2.00, 3.00, 4.00, 5.00, 5.25, 5.50, 5.75, 6.00, 6.25, 6.50, 6.75, 7.00, 7.50, 8.00, 10.00, 12.00, 16.00, 24.00, 48.00, 72.00, and 96.00 hours after dosing.

Five milliliters of blood were drawn into Tripotassium Ethylenediaminetetraacetic Acid (K3EDTA) anticoagulant tubes for each sample. To maintain sample stability, the tubes were submerged in freezing water immediately after collection. Samples were centrifuged at 4000 rpm for 5 minutes at a controlled temperature of 5°C ± 3°C within an hour of the final blood draw. For subsequent study, the resultant plasma was thereafter kept in a low-temperature freezer at -55°C.

Using Coenzyme Q₉ as the internal standard, a validated bioanalytical method developed to quantify the analyte, Coenzyme Q₁₀, in human plasma. Since the body naturally has Coenzyme Q₁₀, a conventional addition procedure was used to ensure precise quantification. The analyte concentration in the biological matrix was determined using this method for both the analysis of research samples and the preparation of calibration standards and quality control samples.

An AB Sciex Triple Quad 4500 mass spectrometer performing in Multiple Reaction Monitoring (MRM) mode with positive ionization was used for the analysis. Liquid-Liquid Extraction (LLE) from plasma samples treated with K3EDTA as an anticoagulant was a component of the sample preparation process. A chromatographic apparatus with a HyPURITY™ C8 column (100 × 4.6 mm) and an autosampler stored at 10°C was used for analyzing the extracted samples.

Acetonitrile, 2-propenol, and 0.1% formic acid were the components of the mobile phase, which was provided isocratically at a flow rate of 1.000 mL/min in a 90:10 (v/v) ratio. The injection volume was 2 μL, and the run time was 6.0 minutes in total. An 80:20 (v/v) ratio of acetonitrile to water was used as the rinse solution.

Coenzyme Q₁₀ and Coenzyme Q₉ had retention periods of approx 4.70 and 3.80 minutes, respectively. The peak area ratio was used for quantification, and Analyst Software version 1.7.3 was used for analysis. For a concentration range of 50.000 ng/mL to 8000.000 ng/mL, the method demonstrated linearity using a 1/X² (1/X*X) weighting factor for calibration. While stock and working solutions were stored in polypropylene tubes at temperatures ranging from 2°C to 8°C, matrix samples were kept at -70°C ± 10°C. There was no need for any extra specific conditions beyond those mentioned, and the method was not light-sensitive. It's crucial to remember that retention times are not considered specific method requirements, but rather assay properties.

Safety analysis

Vital signs, clinical observations, and Adverse Events (AEs) were continuously tracked during the course of the study. From the moment the drug was administered until 24 hours after the last blood sample had been collected, safety laboratory testing was carried out. Throughout every aspect of study, clinical investigators kept a close eye out for any adverse events.

Statistical analysis

Phoenix® WinNonLin® software version 8.4 or higher was used to assess major pharmacokinetic parameters and plasma drug concentrations. SAS® software (version 9.4 or higher, SAS® Institute Inc., USA) was used to statistically evaluate pharmacokinetic parameters including Cmax and Tmax.

The pharmacokinetic properties of the supplied formulations were evaluated using descriptive statistics, such as sample size (N), mean, Standard Deviation (SD), median, minimum, maximum, coefficient of variation (%CV), and geometric mean. The assessment of safety outcomes also made use of quantitative data, including mean, SD, median, minimum, and maximum values.

Results

Overview of baseline participant characteristics

Out of the 25 volunteers that underwent screening for the study, 11 had been excluded in accordance with the specified exclusion criteria. Finally, a total of 14 males were recruited (Figure 1). In Table 1, comprehensive demographic data is displayed (Table 1). The individuals were 35.29 ± 5.3 years old on average, 168 ± 7.1 cm tall, 71.63 ± 6.7 kg in weight, and had an average Body Mass Index (BMI) of 25.55 ± 2.5 kg/m². The inclusion and exclusion criteria of the study were entirely satisfied by every participant, and there were no deviations from the protocol. (Figure 1).

Figure 1: Participant flow diagram. N: number of participants.

Table 1: Baseline Demographic Characteristics

Pharmacokinetic analysis data

During each study period, samples were collected from every subject at 25 distinct times, and the plasma concentrations of Ultra Q 300 and other brand having similar composition were subsequently analyzed (Figure 2).

The mean plasma concentration–time profile and associated semi-logarithmic curve are shown in Figure 2.

Figure 2: Average plasma concentration–time profile and corresponding semi-logarithmic plot.

The data showed that the plasma concentration curves of Ultra Q 300 and other brand having similar composition differed noticeably. The Test formulation (Ultra Q 300) typically had somewhat higher Cmax values in the majority of patients, even though the Cmax values for both formulations showed a comparable pattern across participants-indicating similar absorption characteristics. This implies that some people may experience increased systemic exposure as a result of the Test product. Cmax's adjusted geometric mean ratio (90% CI) ranged from 102.27% to 118.47%, with a value of 110.07%.

The average Cmax values for Ultra Q 300 and other brand having similar composition were 1345.129 ng/mL and 1181.796 ng/mL, respectively (Tables 2 and 3).

Table 2: Overview of Pharmacokinetic (PK) Parameters.

Table 3: Bioequivalence statistics of pharmacokinetic parameters.

Safety results

No significant adverse responses or serious adverse events were noted, and all subjects maintained stable vital signs and good general health throughout the research. These results show that in healthy individuals, both Ultra Q 300 and other brand having similar composition capsules have good safety profiles and are well-tolerated.

Discussion

Regulatory bodies in the US and Europe have approved Coenzyme Q10 as a dietary supplement. The bioavailability and safety profiles of Ultra Q 300 and other brand having similar composition were evaluated and compared in this single-center bioavailability study using a randomized, open-label, crossover design.

Earlier studies on co-enzyme Q10 have highlighted the high inter-individual variability among subjects [18]. A study examining the effects of age and sex on serum CoQ10 levels in 860 European adults aged 18 to 82 found an inverse U-shaped pattern between CoQ10 concentration and age. Women consistently had lower cholesterol-adjusted CoQ10 levels than men, regardless of age. In both sexes, CoQ10 levels declined in older individuals [20]. Notable racial differences have been observed in coenzyme Q10 levels, with Black individuals showing significantly higher CoQ10 values compared to white individuals. However, the reference ranges for total CoQ10 and ubiquinol-10 in Blacks, Chinese, and Indians still fall within the established reference range for white populations [21].

Given these factors, this study specifically enrolled healthy male participants aged 18 to 45 years to maintain consistency and reduce variability.

Coenzyme Q10 has been shown to improve New York Heart Association (NYHA) functional class, lower Brain Natriuretic Peptide (BNP) levels, decrease overall mortality, and decrease hospitalization rates in heart failure patients. Additionally, it raises the left ventricular ejection fraction and increases 6- minute walk test scores, both of which are beneficial without causing any noticeable adverse effects [22]. Even at higher doses, CoQ10 is generally well tolerated and has demonstrated promise in preventing migraines [23].

Furthermore, by substantially lowering levels of Tumor Necrosis Factor-Alpha (TNF-α), Interleukin-6 (IL-6), and C-Reactive Protein (CRP), CoQ10 has shown anti-inflammatory properties. However, additional well-controlled clinical trials are required to prove its therapeutic efficacy and provide optimal dose guidelines because of the unpredictability and limitations in the current research [24].

CoQ10 has been found to significantly alleviate fatigue, with greater effects observed at higher doses and with longer treatment periods. However, additional research is needed to estimate the long-term benefits once supplementation is discontinued [25]. CoQ10 has demonstrated promise in enhancing glucose metabolism, reducing inflammation, and balancing hormone levels in patients with PCOS, with significant reductions in Fasting Plasma Glucose (FPG) and HOMA-IR. Nevertheless, larger and well-designed randomized controlled studies are required to validate its effectiveness and safety [26]. GF Bacillus antioxidative enzyme SOD (GF101) demonstrated similar effectiveness to CoQ10 in addressing female infertility and significantly lowered total cholesterol and LDL levels. It may be a valuable antioxidant alternative, especially for women with dyslipidemia [27]. CoQ10 has been shown to significantly enhance biomarkers of oxidative damage such as Total Antioxidant Defense (TAC), Malondialdehyde Concentration (MDA), and Superoxide Dismutase Enzyme Activity (SOD), when compared to a placebo. However, additional long-term studies involving uniform patient populations are necessary to better understand its overall effectiveness and variability in individual responses [28].

By lowering the synthesis of metalloproteinases and interleukin-6, CoQ10 has been shown to inhibit the development of wrinkles caused by UVB radiation in both lab and real-world models. Collagenase, which degrades collagen fibers, is especially significant among these enzymes. CoQ10 contributes to wrinkle reduction and skin renewal by preserving the integrity of dermal fibers through the inhibition of collagenase.

Furthermore, CoQ10 has demonstrated encouraging results when administered to treat oxidative stress associated with Down syndrome in children. The antiangiogenic and cholesterol-lowering properties of CoQ10 have been emphasized in several research, especially in patients with breast cancer receiving tamoxifen treatment. Further, a 2008 case report detailed a patient who experienced chronic intestinal pseudoobstruction and improved after taking CoQ10 medication. The patient had maternally inherited diabetes and deafness, a hereditary form of diabetes that affects insulin secretion [29].

CoQ10 is initially absorbed by the liver, where it is incorporated into lipoproteins and then distributed throughout the bloodstream. This process likely contributes to its extended elimination phase, with a half-life of approximately 33 hours. In terms of metabolism, CoQ10 is broken down by cytochrome P450 enzymes [30]. To prevent any carryover effects from the previous treatment cycle. In this study, the washout period was intended to be longer than five times the half-life of the medication. This approach ensured that drug concentrations in all individuals were undetectable by bioassays prior to the start of the next dosing phase. Each participant's pre-dose plasma levels of coenzyme Q10 were actually below the detectable limit, indicating that the trial protocols specified washout time was sufficient.

In this study, pharmacokinetic data from individual subjects will be excluded if outliers are detected to maintain the integrity and accuracy of the analysis. Participants were excluded if they had known hypersensitivity to CoQ10 or its components, significant medical conditions affecting major body systems, recent use of medications or vaccines (within 14 days), history of asthma, nasal polyps, or NSAID-induced reactions, recent consumption of grapefruit, xanthine-containing foods, tobacco, or alcohol, or were smokers within the last 6 months. A history of psychiatric disorders or seizures, substance abuse, abnormal laboratory results, blood donation within the last 90 days, participation in other clinical trials, swallowing difficulties, positive hepatitis B, hepatitis C, or HIV tests, atypical diets, and a history of dystonic reactions were among the other exclusion criteria. Crucially, there were no outliers among the 14 subjects who finished both research cycles. Thus, these 14 participants are included in the safety analysis set, bioavailability analysis set, and whole analysis set.

In this bioavailability estimation, key parameters including Tmax, and Cmax were analyzed as primary measures [31]. Additionally, the pharmacokinetic parameter ratios comparing the generic drug to the reference drug are required to fall within a 90% confidence interval ranging from 80% to 125% [32].

The pharmacokinetic analysis of Ultra Q 300 (Test) and other brand having similar composition (Reference) demonstrated that both formulations had comparable absorption patterns, with very slight subject-to-subject differences evident in the Cmax values. The Test formulation had a plasma concentration that was roughly 12.93% higher than the Reference, with an average Cmax of 1181.796 ng/mL and 1345.129 ng/mL for the Test product. Comparable absorption rates were indicated by Tmax values for both formulations, which varied between 5.5 and 7.5 hours. A statistical power of above 99.0% and a variability rate of 10.94% were found in the trial's evaluation of individual variability and accuracy for Cmax. These findings verify that there was a sufficient sample size to evaluate the Ultra Q 300 and other brand having similar composition equivalency.

Overall, Ultra Q 300 and other brand having similar composition are closely aligned in systemic exposure, with Ultra Q 300 showing a modest increase. Importantly, both formulations were well tolerated with no adverse events or safety concerns reported during the study, indicating that the increased systemic exposure from Ultra Q 300 also did not compromise safety. The improved bioavailability may be attributed to better formulation characteristics of Ultra Q 300, such as enhanced solubilization or absorption-promoting excipients. The current data, obtained from only 14 healthy individuals, supports the interpretation of similar systemic exposure between the formulations.

Conclusion

This study demonstrated that Ultra Q 300 has improved bioavailability, while maintaining a similar absorption profile and excellent safety in healthy adults. Both formulations were well tolerated, with no adverse events reported. The improved systemic exposure observed with Ultra Q 300 may translate to better therapeutic effectiveness in clinical practice. These findings support Ultra Q 300 as a safe, effective, and beneficial for individuals seeking enhanced energy metabolism or antioxidant support.

Data Availability Statement

The raw data supporting the conclusion of this article will be made available by the authors, without undue reservation.

Ethics Statement

The studies involving humans were approved by the Shah Lifeline Hospital and Heart Institute Ethics Committee reviewed the protocol and gave final approval for the trial to proceed (approval number: SLH-IEC/2025/026). The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.

Author Contributions

Dr. S. M. Rahman, Dr. Honey Qureshi: Manuscript review; Dr. Poorneshwar Sawant, Mr. Sunil Kulkarni: Conceptualization, Study design. Dr. Ravindra Mote: Clinical study conduct, Data collection, Statistical analysis, Manuscript drafting. Dr. Parikshit Champanerkar: Bioanalytical method development, Sample analysis, Data interpretation, Manuscript editing.

Funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Meyer Organics Private Limited, Thane, and Mumbai. The founder helps pay for this study and has no role in study design, data collection and analysis, or preparation of the manuscript.

Acknowledgments

We thank all enrolled participants, investigators, and people who contributed to this study.

Conflict of Interest

All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publishers Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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