Active Targeted Macrophage-mediated Delivery of Catalase to Affected Brain Regions in Models of Parkinson's Disease

Yuling Zhao^1,2, Matthew J. Haney^1,2, Vivek Mahajan^1,3, Benjamin C. Reiner⁴, Anna Dunaevsky⁴, R. Lee Mosley^1,5,6, Alexander V. Kabanov^1,2, Howard E. Gendelman^1,2,5,6 and Elena V. Batrakova^1,2*

¹Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, Nebraska, USA

²Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA

³Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA

⁴Developmental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA

⁵Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, USA

⁶Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA