A Rare Intronic Variation of Presenilin-1 (rs201992645) is Associated with Alzheimer’s Disease and Down Syndrome Birth

Pranami Bhaumik¹, Priyanka Ghosh¹, Sujoy Ghosh², Kausik Majumdar³, Sandip Pal⁴, Biswanath Sarkar⁵, AbhishiktaGhosh Roy⁵, Abhinandan Chakraborty¹ and Subrata Kumar Dey^1*

¹Human genetics Research Unit, Department of Biotechnology, School of Biotechnology and Biological Sciences, West Bengal University of Technology, India

²Genetics & Genomics Research Unit, Department of Zoology, University of Calcutta, (Ballygunge Science college campus), India

³Department of Elderly Medicine, National Neurosciences Centre/Peerless Hospital, Panchasayar, India

⁴Department of Neurology, Burdwan Medical College, India

⁵DNA laboratory, Anthropological Survey of India, 27 Jawaharlal Nehru Road, Kolkata, India