Journal of Bioequivalence & Bioavailability

Wahajuddin

Wahajuddin
Division of Pharmacokinetics and Metabolism, Central Drug Research Institute
India

Biography

Wahajuddin is a scientist in Pharmacokinetics Metabolism Division at Central Drug Research Institute Council for Scientific and Industrial Research Govt of India, Lucknow, India. He has studied at National Institute of Pharmaceutical Education and Research an institute of national importance under the aegis of ministry of chemicals and fertilizers Govt of India, S A S Nagar, Punjab, India. He is also registered patent agent at Indian Patent Office. He is life member of many professional societies viz Indian Pharmacological Society Indian Society of Mass Spectrometry etc.

Research Interest

Bio-analysis: Bio-analytical method development and validation, as per the regulatory (US-FDA, ICH etc.) guidelines, on HPLC and LC-MS/MS platform for quantitative determination of small molecules (NCEs/Drugs and/or metabolites) in different biological matrices
Pharmacokinetic studies: Characterization of the in vivo pharmacokinetics (bio-availability, dose-proportionality, gender variation, inter-species comparison) following oral and parenteral routes of administration in animal models. Toxicokinetic and tissue distribution studies to support regulatory toxicology
Metabolism, Metabolite Identification and CYP Phenotyping: In vitro/in vivo Metabolism of new chemical entities and/or drugs using animal models, scaling preclinical and in-vitro data to predict events in humans for preliminary assessment of safe exposure levels, determination of the metabolite profiles of drug candidates using liver microsomes/human recombinant CYP450 isozymes, Identify Phase I or Phase II enzymes responsible for metabolite formation, predict drug interactions due to inhibition or induction of drug metabolizing enzymes
Interaction Studies: Drug-drug, herb-drug and food-drug interaction studies for suggesting benefits (as potential combination)/risks of the same in therapies
Biopharmaceutics: Permeability/Absorption Characterization Studies across Parallel Artificial Membrane Permeability Assay (PAMPA) and in situ rat model, Protein Binding and Simulated Gastro-intestinal Stability for new chemical entities/drugs