Journal of Pharmacovigilance

Sun Hao

Sun Hao
Department of Medicine
University of California, San Diego, San Diego, CA, USA

Biography

I am an outstanding scientist in the area of integrin activation and signaling transduction in the pathogenesis of gut inflammation. As a lymphocyte homing receptor, integrin a4b7 targets lymphocytes in the bloodstream to mucosal tissues and especially the gut. Understanding the regulatory mechanism of a4b7 ligand specific binding and its associated signaling pathways is important for the development of new therapeutics for IBD. Having worked and studied in this field for more than ten years, my research has had a lasting impact on cell migration and gut immunity. As PI on several Chinese fellowships/grants and a AHA fellowship in US, I laid the groundwork for the proposed research by establishing IBD models, developing effective measures of IBD disease index, integrin activation, lymphocyte migration and adhesion and Treg cells function. In addition, I successfully collaborate with other clinical researchers to carry out studies on samples from IBD patients. The goal of my career research is to provide new insights into the regulation of integrin activation and signaling transduction in the pathogenesis of gut inflammation.

Research Interest

I am an scientist in the area of integrin activation and signaling transduction in the pathogenesis of gut inflammation. As a lymphocyte homing receptor, integrin a4b7 targets lymphocytes in the bloodstream to mucosal tissues and especially the gut. Understanding the regulatory mechanism of a4b7 ligand specific binding and its associated signaling pathways is important for the development of new therapeutics for IBD. Having worked and studied in this field for more than ten years, my research has had a lasting impact on cell migration and gut immunity. As PI on several Chinese fellowships/grants and a AHA fellowship in US, I laid the groundwork for the proposed research by establishing IBD models, developing effective measures of IBD disease index, integrin activation, lymphocyte migration and adhesion and Treg cells function. In addition, I successfully collaborate with other clinical researchers to carry out studies on samples from IBD patients. The goal of my career research is to provide new insights into the regulation of integrin activation and signaling transduction in the pathogenesis of gut inflammation.

 The areas of my expertise include: leukocyte trafficking, inflammatory bowel diseases, neutrophil biology, integrin biology, vascular biology, immunological synapse, gastroenterology, cancer metastases

 Here I list some keywords describing my expertise:

Cell adhesion; Rolling and arrest; Leukocyte trafficking; Integrin activation; Inflammatory bowel disease; Autoimmune disease; GPCR proteins; Angiogenesis; Immunological synapse (IS); Cancer metastases.