Mark T Muller
Professor, Department of of Molecular Biology and Microbiology
University of Central Florida, USA
Despite a known role for inappropriate gene silencing in cancer, DNA methylation reversal pathways are not understood. Dr. Muller’s group has scovered that DNA methylation patterns are erased and reset following double stranded DNA break repair, demonstrating a plausible link between DNA damage and silencing of tumor suppressor genes resulting in malignant growth phenotypes. 1980-1986 Assistant Professor of Microbiology, Ohio State University. 1986-1987 Associate Professor of Microbiology, Ohio State University. 1987- Associate Professor of Molecular Genetics, Ohio State University. 1989-90 NIH Study Section (NCI-NCNPDDG, Special Study Section) 1989-1993 American Cancer Society Study Section 1991-1992 Sabbatical, University of British Columbia (Dr. Michael Smith, Nobel Laureate, UBC) 1991-1992 Fogarty International Fellowship Award 1993 Professor of Molecular Genetics, Ohio State University 1993-Board member, DNA Protein, Ltd. 1995-97 Scientific Advisory Board (Chair), Visual Genomics, Inc. 1997- NIH Study Section (Reviewer for Comprehensive Cancer Center Grants) 1998-00 NSF Study Section, REU Program 2001-2003 Co-Director, Experimental Therapeutics Program, OSU Comprehensive Cancer Center 2002- Board of Directors, Genomics USA 2003- Chair, Scientific Advisory Board, Methylation, Ltd. 2003- Chair, Scientific Advisory Board; Member, Board of Directors of TopoGEN, Inc 2004-Professor of Molecular Biology and Microbiology, University of Central Florida 2004- Biomolecular Sciences Center, University of Central lorida 2005- President and CEO, TopoGEN, Inc. 2007- Chair, Scientific Advisory Board, CareCyte Biologics, Inc. 2007- Professor of Medicine, UCF College of Medicine.
DNA Repair, Anti-cancer drug development, Bacterial Gyrase and topoisomerase IV Homologous recombination/repair telomerase aging eukaryotic topoisomerases (I,II, III).