Assistant Professor, Department of Internal Medicine and Medical Specialties
Sapienza University of Rome, Italy
Dr. Mario Arciello is a researcher of “Sapienza” University of Rome. He’s a biologist graduated in 2004 at “Tor Vergata” University of Rome with an experimental thesis in Biochemistry. He has focused its early scientific activity on the study of copper homeostasis alteration in cultured neuronal cells models for Menkes and Wilson diseases, two inherited diseases paradigm of this condition, mainly on its role in the mitochondrial dysfunctions and oxidative stress occurrence. His acquired knowledge led him to study these topics also in the etiopathogenesis of neurodegenerative disorders like Alzheimer’s disease (AD) and the familial form of Amyotrophic Lateral Sclerosis (fALS). After the achievement of the PhD degree in Cellular and Molecular Biology in the 2009 at “Tor Vergata” University of Rome, he has focused its scientific research interests on the molecular pathogenesis of liver diseases, mainly hepatitis due to C virus (HCV) infection and non-alcoholic fatty liver disease (NAFLD). In particular, his investigation topics are the role of oxidative stress, mitochondrial dysfunctions, morphogens and tumor suppressors signaling pathways in liver diseases onset and progression. Dr Arciello is member of Associazione Italiana per lo Studio del Fegato (AISF) and of European Association for the Study of the Liver (EASL).
Menkes’ and Wilson’s Diseases.
Liver diseases (e.g. NAFLD and HCV infection)
Oxidative stress and antioxidant defenses