Journal of Bioequivalence & Bioavailability

Jadwiga Frelek

Jadwiga Frelek
Institute of Organic Chemistry, Polish Academy of Sciences
Poland

Biography

Jadwiga Frelek Professor of Chemistry 1972 to 1978 PhD Department of Chemistry University of Warsaw  Thesis theme: The synthesis and reactivity of some trifunctional 3610 substituted ABsecocholestanes as precursors of the heteroanalogues of natural systems by Professor WJ Rodewald 1968 to 1990 University of Warsaw Department of Chemistry Chair of Natural Products as lecturer and senior scientist; 1990 to 2006 Institute of Organic Chemistry of the Polish Academy of Sciences as senior researcher and as associate professor; 2006 to till now full professor.

Research Interest

Our current research is directed towards three dimensional molecular structures elucidation of selected organic compounds in the solution and/or solid state by means of chiroptical methods, circular dichroism (CD) in particular. Currently we are focusing on the structure-chiroptical properties’ relationship of classical and non-classical ß-lactam analogues, with an emphasis on carba-analogues of penicillin’s and cephalosporin’s. Special attention is devoted to the stereostructure determination of transparent molecules. For this purpose, we developed a methodology which uses various complexes with two transition metal atoms linked together by a single or multiple bond of general formula M2(OCOR)4, with M = Mo, Rh, Ru or Re. These achiral complexes act as auxiliary chromophores. After the exchange of achiral ligands of the stock complex for different types of chiral ligands, e.g., amino acids, glycols, aminols, diamines, alcohols, amines, etc., optically active complexes are formed. CD of these complexes can easily be measured and used for the correlation between signs of Cotton effects (CEs) obtained and the structure of investigated compounds.