Dr. Saeed El-Ashram
Distinguished Researcher, School of Life Science and Engineering
Foshan University, China
Saeed El-Ashram is an Associate Professor of Parasitology, Faculty of Science, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt. He is the holder of several issued and pending patents in the field of Parasitology. He is also the Inventor of “Compositions and methods of enhancing immune responses to Eimeria” (United States Patent 8956849). Dr. Saeed El-Ashram scientific interests include Parasitology, Immunology, Veterinary Medicine and Next -Generation Sequencing (MiSeq and HiSeq). His recent publications include Electrical cream separator coupled with vacuum filtration for the purification of eimerian oocysts and trichostrongylid eggs, Clustering by fast search and merge of local density peaks for gene expression microarray data, Exploring the microbial community (microflora) associated with ovine Haemonchus contortus (macroflora) field strain, Gel Mapping to Differentiate between Sporozoites of Two Immunologically Distinct Strains of Eimeria maxima (Strains M6 and Guelph ), Interferon-Gamma Release Assay,Exploring Early and Late Toxoplasma gondii Strain RH Infection by Two-Dimensional Immunoblots of Chicken Immunoglobulin G and M, and Mycoplasma gallisepticum MGA_0676 is a membrane-associated cytotoxic nuclease with a staphylococcal nuclease region essential for nuclear.
The primary focus of my research is to understand how the animal immune system recognizes and responds to parasitic infections with and/or without microbial community. Some are the causative agents of major diseases of humans, such as toxoplasmosis, cryptosporidiosis, alveolar echinococcosis and fasciolosis. Others are a huge financial burden to food producers because of the effects these parasites have on domestic animals, for example, coccidiosis and cryptosporidiosis (livestock and poultry), and fasciolosis and haemonchosis (livestock). Another area of research in my laboratory investigates the inter-species dynamics in mixed parasitic-bacterial, fungal, or viral infections particularly those with clinical and therapeutic implications. The overall target of my research is to provide information that will aid in the design of novel therapeutic strategies aimed at the prevention and/or treatment of these complicated infections. To achieve this objective, we are utilizing new technology, including Proteomics, Immunoproteomics, Mass Spectrometry, Next Generation Sequencing, Tetramers, Real-time PCR, Immunohistochemistry and Bioinformatic and Flow Cytometry Analyses to dissect the host-pathogen interactions in single or combined infections. The laboratory also deciphers the formation and evolution of host specialization in the foodborne illnesses, such as Salmonella spp., Clostridium perfringens, Campylobacter jejuni and Bacillus cereus by building a genome-based phylogeny and studying the Whole genome sequencing (WGS) as an effective and rapid surveillance tool of foodborne disease.