Journal of Nanomedicine & Nanotechnology

Tissue Testing Technologies LLC, North Charleston, SC, USA

Biography

Zhenzhen Chen is affiliated to Tissue Testing Technologies LLC. He is a recipient of many awards and grants for his valuable contributions and discoveries in major area of subject research. His international experience includes various programs, contributions and participation in different countries for diverse fields of study.  His research interests reflect in his wide range of publications in various national and international journals.
 

Publications

• Commentary   
  Advances in Viable Ice-free Cryopreservation of Heart Valves
  Author(s): Kelvin G.M. Brockbank*
  
  Investigation of heart valve cryopreservation has been employed as a model for development of new methods of tissue preservation based upon vitrification and nanowarming using Fe nanoparticles. Cryoprotectant cytotoxicity can be reduced by performing the last cryoprotectant/nanoparticle exposure step below zero degrees centigrade at -10C. Tissue viability outcomes can be improved by supplementation of cryoprotectant formulations with disaccharides and nanowarming can rewarm such complex tissues with retention of cell viability from storage temperatures below -135ºC to -25ºC in 80-100 seconds. It is anticipated that ice-free tissue cryopreservation methods for tissues up to 50 mLs can be developed that do not require the use of nanowarming, since we are already close to achieving this with heart valves at 30 mL volumes. However, at larger volumes nanowarming will likely conti.. View more»
  

  DOI: 10.35248/2157-7439.21.12.566

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