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Shiva Alle
Department of Medicine, The Royal Bournemouth Hospital, Castle Lane East, Bournemouth, BH7 7DW, UK
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Commentary
Progression of Type 2 Diabetes Mellitus: Early Life Factors
Author(s): Shiva Alle*
Type 2 diabetes mellitus is multifactorial disorder with a complicated Aetiology that includes genetic, epigenetic, and environmental aspects. In recent years, evidence from both human and animal models revealed early life variables to adult diabetes risk programming. Organ development is critical during the foetal and neonatal phases. Many maternal factors during pregnancy, including malnutrition, health (hyperglycemia and obesity), lifestyle (smoking, drinking, and a junk food diet), hormone administration, and even stress, may contribute to the risk of diabetes in infants later in life. Catch-up growth, lactation, glucocorticoids, and stress have all been implicated in the development of insulin resistance or T2DM in neonates. .. View more»