Advances in Pharmacoepidemiology and Drug Safety

Department of Public Health, La Trobe University, Bundoora, Victoria, Australia

Publications

• Research Article   
  Duration of Antidepressant Use and Risk of New Onset Drug Treated Diabetes Derived from Australian Administrative Data
  Author(s): Shaun Francis Purkiss*
  
  Introduction: Treatment with antidepressants may be associated with a risk of diabetes. Direct drug effects might play a role, but weight gain and impaired glucose regulation are other factors that may contribute to diabetes risk. Objective: We have utilised an Australian administrative pharmaceutical database to examine the association of new onset drug-treated diabetes with specific antidepressant treatments and durations. Methods: A longitudinal cohort study with quasi-experimental design using administrative pharmaceutical data was performed. Uninterrupted treatments of 0.5-4 years with specific antidepressant agents prescribed to individuals were defined and the relative risks of new-onset drug treated diabetes calculated for age, sex, and treatment duration. Results: Seven antidepre.. View more»
  

  Abstract PDF