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Ronaldo Zucatelli Mendonça
Laboratory of Parasitology, Butantan nstitute, São Paulo/SP, Brazil
Publications
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Research Article
The Anti-Apoptotic Effect of Lonomia obliqua Hemolymph is Associated with the Mitochondria Pathway
Author(s): Ronaldo Zucatelli Mendonça* and Luciana Moreira Martins
The apoptosis death is a very important factor in production processes that limited the industrial production of some proteins of economic interest. However, one of the forms to increase the cellular productivity would be inhibit or attenuate the cellular death. Recently we have demonstrated the presence of a potent anti-apoptotic protein in Lonomia obliqua hemolymph which extends the cell culture viability through apoptosis prevention. By the other side, has been reported that mitochondria have one important action in the apoptosis control process, being that Mitochondria Membrane Permeabilization (MMP) can be an important stage in this process. MMP associated or not with the loss of the electrochemical potential of the mitochondria and alteration of the matrix is responsible for the inter membranes protein release (e.g. cytochrome c, the AIF, etc) of cytos.. View more»